Recent advances in cutaneous lymphoma—implications for current and future classifications

Goodlad, J. R., Cerroni, L. and Swerdlow, S. H. (2023) Recent advances in cutaneous lymphoma—implications for current and future classifications. Virchows Archiv, 482(1), pp. 281-298. (doi: 10.1007/s00428-022-03421-5) (PMID:36278991) (PMCID:PMC9852132)

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The Revised European-American Classification of mature lymphoid neoplasms published in 1994 and the 2001, 2008 and 2016 WHO classifications that followed, were the product of international collaboration and consensus amongst haematopathologists, geneticists, molecular scientists and clinicians. Primary cutaneous lymphomas were fully incorporated into this process following the publication of the WHO-EORTC classification of cutaneous lymphomas in 2005. The definition, diagnostic criteria and recommended studies for primary cutaneous lymphoma continue to be refined. The 2022 International Consensus Classification represents the most recent update and an overview of all the main entities presenting primarily in the skin, together with the major changes in classification, are summarized herein. Primary cutaneous marginal zone lymphoma is segregated from other extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) and downgraded to a lymphoproliferative disorder in line with its markedly indolent behaviour. In addition, two subtypes are recognised, based largely but not exclusively on whether they are heavy chain class-switched or IgM positive. Similarly, in keeping with a trend to greater conservatism, primary cutaneous acral CD8 positive T cell lymphoma is now also classified as a lymphoproliferative disorder. In addition, significant new insights into the biology of primary cutaneous lymphoma have also recently been forthcoming and will be presented. These studies have enhanced our knowledge of genetic, epigenetic and transcriptional changes in this group of diseases. They not only identify potential targets for novel therapies, but also raise as yet unanswered questions as to how we categorise cutaneous lymphomas, particularly with respect to relationships with similar lymphomas at extracutaneous sites.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Goodlad, Dr John
Authors: Goodlad, J. R., Cerroni, L., and Swerdlow, S. H.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Virchows Archiv
ISSN (Online):1432-2307
Published Online:24 October 2022
Copyright Holders:Copyright © Crown 2022
First Published:First published in Virchows Archiv 482(1): 281-298
Publisher Policy:Reproduced under a Creative Commons License

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