Nguyen, T. X. et al. (2023) Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed part I: serum proteomes. Journal of Proteomics, 270, 104740. (doi: 10.1016/j.jprot.2022.104740) (PMID:36191802)
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Abstract
This study examines whether maternal low ω6:ω3 ratio diet and offspring SW supplementation can improve offspring immunity and performance by elucidating the effects on piglet serum proteome. A total of 16 sows were given either a standard (CR, 13:1) or low ω6:ω3 ratio diet (LR, 4:1) during pregnancy and lactation and their male weaned piglets were supplemented with SW powder (4 g/kg, SW) or not (CT) in a 21-day post-weaning (PW) diet. Four PW piglet groups were then identified based on dam and piglet treatment, namely CRCT, CRSW, LRCT, and LRSW (n = 10 each). Piglet serum collected at weaning and d21 PW were analysed (n = 5 each) using TMT-based quantitative proteomics and validated by appropriate assays. The differentially abundant proteins (n = 122) displayed positive effects of maternal LR diet on anti-inflammatory properties and innate immune stimulation. Progeny SW diet activated the innate immunity and enhance the host defence during inflammation. These data demonstrate the value of decreasing ω6:ω3 ratio in maternal diet and SW supplementation in PW piglet's diet to boost their immunity and anti-inflammation properties.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McLaughlin, Dr Mark and McGill, Mrs Suzanne and Burchmore, Dr Richard and Eckersall, Professor David and Weidt, Dr Stefan and Nguyen, Thi Xuan |
| Authors: | Nguyen, T. X., Agazzi, A., McGill, S., Weidt, S., Perricone, V., Han, Q. H., Gelemanović, A., McLaughlin, M., Savoini, G., Eckersall, P. D., and Burchmore, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Proteomics |
| Publisher: | Elsevier |
| ISSN: | 1874-3919 |
| ISSN (Online): | 1876-7737 |
| Published Online: | 30 September 2022 |
| Copyright Holders: | Copyright © 2022 Elsevier B.V. |
| First Published: | First published in Journal of Proteomics 270: 104740 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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