Near-field probing of optical superchirality with plasmonic circularly polarized luminescence for enhanced bio-detection

Tabouillot, V. et al. (2022) Near-field probing of optical superchirality with plasmonic circularly polarized luminescence for enhanced bio-detection. ACS Photonics, 9(11), pp. 3617-3624. (doi: 10.1021/acsphotonics.2c01073) (PMID:36411820)

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Nanophotonic platforms in theory uniquely enable < femtomoles of chiral biological and pharmaceutical molecules to be detected, through the highly localized changes in the chiral asymmetries of the near fields that they induce. However, current chiral nanophotonic based strategies are intrinsically limited because they rely on far field optical measurements that are sensitive to a much larger near field volume, than that influenced by the chiral molecules. Consequently, they depend on detecting small changes in far field optical response restricting detection sensitivities. Here, we exploit an intriguing phenomenon, plasmonic circularly polarized luminescence (PCPL), which is an incisive local probe of near field chirality. This allows the chiral detection of monolayer quantities of a de novo designed peptide, which is not achieved with a far field response. Our work demonstrates that by leveraging the capabilities of nanophotonic platforms with the near field sensitivity of PCPL, optimal biomolecular detection performance can be achieved, opening new avenues for nanometrology.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hajji, Dr Maryam and Sutherland, Professor Andrew and TABOUILLOT, Victor and Kumar, Dr Rahul and Gadegaard, Professor Nikolaj and Clarke, Ms Rebecca and Karimullah, Dr Affar and Laborda Lalaguna, Paula and Thomson, Dr Drew and Kadodwala, Professor Malcolm
Authors: Tabouillot, V., Kumar, R., Lalaguna, P. L., Hajji, M., Clarke, R., Karimullah, A. S., Thomson, A. R., Sutherland, A., Gadegaard, N., Hashiyada, S., and Kadodwala, M.
College/School:College of Science and Engineering > School of Chemistry
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:ACS Photonics
Publisher:American Chemical Society
ISSN (Online):2330-4022
Published Online:20 October 2022
Copyright Holders:Copyright © 2022 The Author
First Published:First published in ACS Photonics 9(11): 3617-3624
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173324Mapping the mesoscale structural landscape using "sculpted" chiral plasmonic fieldsMalcolm KadodwalaEngineering and Physical Sciences Research Council (EPSRC)EP/P00086X/1Chemistry
190883Consortium for advanced materials based on spin chiralityStephen McVitieEngineering and Physical Sciences Research Council (EPSRC)EP/M024423/1P&S - Physics & Astronomy
305796A nano-resonator route to colossal magnetochiral optical effectsMalcolm KadodwalaLeverhulme Trust (LEVERHUL)RF-2019-023\4Chemistry