Jones, K.A. , Paterson, C.A. , Ray, S. , Motherwell, D.W., Hamilton, D.J. , Small, A.D., Martin, W. and Goodfield, N.E.R. (2023) Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography. Journal of Nuclear Cardiology, 30(1), pp. 193-200. (doi: 10.1007/s12350-022-03142-x) (PMID:36417121) (PMCID:PMC9984517)
![[img]](https://eprints.gla.ac.uk/style/images/fileicons/text.png) |
Text
282064.pdf - Published Version Available under License Creative Commons Attribution. 391kB |
Abstract
Background: Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel RNVG phase parameters. Methods: A retrospective study was carried out in a group of 98 patients with HFrEF. LVEF and dyssynchrony were assessed pre and post beta-blockade. Dyssynchrony was assessed using synchrony, entropy, phase standard deviation, approximate entropy, and sample entropy from planar RNVG phase images. Subgroups split by ischemic etiology were also investigated. Results: An improvement in dyssynchrony and LVEF was measured six months post beta-blockade for both ischemic and non-ischemic groups. Conclusions: A significant improvement in dyssynchrony and LVEF was measured post beta-blockade using novel measures of dyssynchrony.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Paterson, Mr Craig and Jones, Dr Kirsty and Martin, Dr William and Hamilton, Dr David and Ray, Professor Surajit and Small, Dr Alexander |
| Authors: | Jones, K.A., Paterson, C.A., Ray, S., Motherwell, D.W., Hamilton, D.J., Small, A.D., Martin, W., and Goodfield, N.E.R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering > School of Mathematics and Statistics > Statistics College of Science and Engineering > School of Physics and Astronomy |
| Journal Name: | Journal of Nuclear Cardiology |
| Publisher: | Springer |
| ISSN: | 1071-3581 |
| ISSN (Online): | 1532-6551 |
| Published Online: | 23 November 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Journal of Nuclear Cardiology 30(1): 193-200 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details