Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography

Jones, K.A. , Paterson, C.A. , Ray, S. , Motherwell, D.W., Hamilton, D.J. , Small, A.D., Martin, W. and Goodfield, N.E.R. (2023) Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography. Journal of Nuclear Cardiology, 30(1), pp. 193-200. (doi: 10.1007/s12350-022-03142-x) (PMID:36417121) (PMCID:PMC9984517)

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Abstract

Background: Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel RNVG phase parameters. Methods: A retrospective study was carried out in a group of 98 patients with HFrEF. LVEF and dyssynchrony were assessed pre and post beta-blockade. Dyssynchrony was assessed using synchrony, entropy, phase standard deviation, approximate entropy, and sample entropy from planar RNVG phase images. Subgroups split by ischemic etiology were also investigated. Results: An improvement in dyssynchrony and LVEF was measured six months post beta-blockade for both ischemic and non-ischemic groups. Conclusions: A significant improvement in dyssynchrony and LVEF was measured post beta-blockade using novel measures of dyssynchrony.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Paterson, Mr Craig and Jones, Dr Kirsty and Martin, Dr William and Hamilton, Dr David and Ray, Professor Surajit and Small, Dr Sandy
Authors: Jones, K.A., Paterson, C.A., Ray, S., Motherwell, D.W., Hamilton, D.J., Small, A.D., Martin, W., and Goodfield, N.E.R.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Mathematics and Statistics > Statistics
College of Science and Engineering > School of Physics and Astronomy
Journal Name:Journal of Nuclear Cardiology
Publisher:Springer
ISSN:1071-3581
ISSN (Online):1532-6551
Published Online:23 November 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of Nuclear Cardiology 30(1): 193-200
Publisher Policy:Reproduced under a Creative Commons License

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