How arrestins and GRKs regulate the function of long chain fatty acid receptors

Alharbi, A. G., Tobin, A. B. and Milligan, G. (2022) How arrestins and GRKs regulate the function of long chain fatty acid receptors. International Journal of Molecular Sciences, 23(20), 12237. (doi: 10.3390/ijms232012237) (PMID:36293091) (PMCID:PMC9602559)

Abstract

FFA1 and FFA4, two G protein-coupled receptors that are activated by long chain fatty acids, play crucial roles in mediating many biological functions in the body. As a result, these fatty acid receptors have gained considerable attention due to their potential to be targeted for the treatment of type-2 diabetes. However, the relative contribution of canonical G protein-mediated signalling versus the effects of agonist-induced phosphorylation and interactions with β-arrestins have yet to be fully defined. Recently, several reports have highlighted the ability of β-arrestins and GRKs to interact with and modulate different functions of both FFA1 and FFA4, suggesting that it is indeed important to consider these interactions when studying the roles of FFA1 and FFA4 in both normal physiology and in different disease settings. Here, we discuss what is currently known and show the importance of understanding fully how β-arrestins and GRKs regulate the function of long chain fatty acid receptors.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Alharbi, Abdulrahman Ghali Meshal and Milligan, Professor Graeme and Tobin, Andrew
• Authors: Alharbi, A. G., Tobin, A. B., and Milligan, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: International Journal of Molecular Sciences
• Publisher: MDPI
• ISSN: 1661-6596
• ISSN (Online): 1422-0067
• Published Online: 13 October 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in International Journal of Molecular Sciences 23(20):12237
• Publisher Policy: Reproduced under a Creative Commons licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
301391		Defining the functional modes of action, and therapeutic potential of targeting, the free fatty acid receptor FFA4 in the lung	Andrew Tobin	Medical Research Council (MRC)	MR/R00305X/1	Institute of Molecular, Cell & Systems Biology