The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain

MacLean, A. E., Hayward, J. A., Huet, D., van Dooren, G. G. and Sheiner, L. (2022) The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain. Trends in Parasitology, 38(12), pp. 1041-1052. (doi: 10.1016/j.pt.2022.09.008) (PMID:36302692)

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Abstract

The mitochondrial respiratory chain is an essential pathway in most studied eukaryotes due to its roles in respiration and other pathways that depend on mitochondrial membrane potential. Apicomplexans are unicellular eukaryotes whose members have an impact on global health. The respiratory chain is a drug target for some members of this group, notably the malaria-causing Plasmodium spp. This has motivated studies of the respiratory chain in apicomplexan parasites, primarily Toxoplasma gondii and Plasmodium spp. for which experimental tools are most advanced. Studies of the respiratory complexes in these organisms revealed numerous novel features, including expansion of complex size. The divergence of apicomplexan mitochondria from commonly studied models highlights the diversity of mitochondrial form and function across eukaryotic life.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:MacLean, Dr Andrew and Sheiner, Dr Lilach
Authors: MacLean, A. E., Hayward, J. A., Huet, D., van Dooren, G. G., and Sheiner, L.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Trends in Parasitology
Publisher:Elsevier (Cell Press)
ISSN:1471-4922
ISSN (Online):1471-5007
Published Online:24 October 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Trends in Parasitology 38(12): 1041-1052
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
311544TBDAndrew MacLeanWellcome Trust (WELLCOTR)221681/Z/20/ZIII - Parasitology
313878Characterization of critical differences between human and parasite respiratory complex IILilach SheinerMedical Research Council (MRC)MR/W002221/1III - Parasitology
307056Lost in translation. A study of the divergent mitochondrial translation pathway of the parasite Toxoplasma gondiiLilach SheinerWellcome Trust (WELLCOTR)217173/Z/19/ZMVLS - Polyomics Facility