MacLean, A. E., Hayward, J. A., Huet, D., van Dooren, G. G. and Sheiner, L. (2022) The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain. Trends in Parasitology, 38(12), pp. 1041-1052. (doi: 10.1016/j.pt.2022.09.008) (PMID:36302692) (PMCID:PMC10434753)
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Abstract
The mitochondrial respiratory chain is an essential pathway in most studied eukaryotes due to its roles in respiration and other pathways that depend on mitochondrial membrane potential. Apicomplexans are unicellular eukaryotes whose members have an impact on global health. The respiratory chain is a drug target for some members of this group, notably the malaria-causing Plasmodium spp. This has motivated studies of the respiratory chain in apicomplexan parasites, primarily Toxoplasma gondii and Plasmodium spp. for which experimental tools are most advanced. Studies of the respiratory complexes in these organisms revealed numerous novel features, including expansion of complex size. The divergence of apicomplexan mitochondria from commonly studied models highlights the diversity of mitochondrial form and function across eukaryotic life.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | MacLean, Dr Andrew and Sheiner, Professor Lilach |
Authors: | MacLean, A. E., Hayward, J. A., Huet, D., van Dooren, G. G., and Sheiner, L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Trends in Parasitology |
Publisher: | Elsevier (Cell Press) |
ISSN: | 1471-4922 |
ISSN (Online): | 1471-5007 |
Published Online: | 24 October 2022 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Trends in Parasitology 38(12): 1041-1052 |
Publisher Policy: | Reproduced under a Creative Commons License |
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