Vink, E. et al. (2022) Viral co-infections in hospitalised COVID-19 patients recruited to the ISARIC WHO CCP-UK study. Open Forum Infectious Diseases, 9(11), ofac531. (doi: 10.1093/ofid/ofac531) (PMID:36381618) (PMCID:PMC9619746)
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Abstract
Objective: To assess the prevalence of viral co-infection in a well-characterised cohort of hospitalised COVID-19 patients, and to investigate the impact of co-infection on disease severity. Methods: Multiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 COVID-19 patients, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge. Results: A co-infecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for co-infection, though this may be due to rarity of co-infection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between co-infection and increased disease severity. Conclusion: Viral co-infection was rare among hospitalised COVID-19 patients in the UK during the first eighteen months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral co-infection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral co-infections going forward.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Scott, Dr Janet and MacLean, Dr Alasdair and McDonald, Dr Sarah and Gunson, Dr Rory and Davis, Dr Chris and Ho, Dr Antonia and Vink, Elen |
| Authors: | Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., Hardwick, H. E., Oosthuyzen, W., Openshaw, P. J. M., Baillie, J. K., Semple, M. G., Ho, A., and on behalf of the ISARIC4C Investigators, |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Open Forum Infectious Diseases |
| Publisher: | Oxford University Press |
| ISSN: | 2328-8957 |
| ISSN (Online): | 2328-8957 |
| Published Online: | 10 October 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Open Forum Infectious Diseases 9(11): ofac531 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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