Effects of Myofibre Architecture on Biventricular Biomechanics: a Simulation Study

Guan, D., Yao, J., Luo, X. and Gao, H. (2019) Effects of Myofibre Architecture on Biventricular Biomechanics: a Simulation Study. In: 6th International Conference on Computational and Mathematical Biomedical Engineering (CMBE 2019), Sendai City, Japan, 10-12 Jun 2019, pp. 248-251. ISBN 9780956291455

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Personalized computational cardiac modelling can provide unqiue insights on heart funciton both physiologically and pathologically. Myofibre architecture is one of the essential components when constructing realistic cardiac biomechanical models. Although ex vivo myofibre datasets are available, many computational studies still use rule-based myofibre reconstruction. In this study, we develop a bi-ventricle neonatal porcine model with myofibres reconstructed by mapping an ex vivo myofibre dataset through a large deformation deformorphic metric mapping (LDDMM) approach, we further compare this model with a corresponding model based on a rule-based approach using the same ex vivo dataset. Our results show that incorporating a realistic myofibre structure can produce larger stroke work, higher ejection fraction and apical twist. The LDDMM-based model outcome is closer to the healthy range compared to the rule-based myofibre reconstruction. This highlights the importance of a realistic myofibre architecture in personalized ventricular modelling.

Item Type:Conference Proceedings
Keywords:Bi-ventricular model, myofibre architecture, biomechanics, LDDMM.
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Guan, Mr Debao and Gao, Dr Hao
Authors: Guan, D., Yao, J., Luo, X., and Gao, H.
Subjects:Q Science > QA Mathematics
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172141EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancerRaymond OgdenEngineering and Physical Sciences Research Council (EPSRC)EP/N014642/1M&S - Mathematics