A comparison of CT-body composition measurements in non-cancer and cancer patients from a single UK centre

McGovern, J., Dolan, R. D. , Maguire, D., Horgan, P. , Laird, B. J. and McMillan, D. C. (2022) A comparison of CT-body composition measurements in non-cancer and cancer patients from a single UK centre. Journal of Frailty, Sarcopenia and Falls, 7(3), pp. 117-122. (doi: 10.22540/JFSF-07-117) (PMID:36119551) (PMCID:PMC9433946)

Abstract

Objectives: Establish the prevalence of low skeletal muscle index and density in our population, by comparing age and sex matched cohorts of patients with and without cancer, using standardized methodology for CT-Body composition (CT-BC). Methods: A retrospective analysis of prospectively collected data. Patients admitted to our institution between 17th March 2020 - 1st May 2020, with confirmed coronavirus disease and imaging suitable for CT-BC (n=52), were age and sex matched with patients undergoing resection for colorectal cancer (n=52). Results: 104 patients were included in the final analysis. 43% (n=45) were male, 77% (n=80) were aged 65 years or older, 50% (n=50) were overweight (BMI ≥25) and 53% (n=55) were systemically inflamed (mGPS ≥1). The prevalence of a low SMI (56% vs. 65%) and low SMD (83% vs. 67%) was similar between cohorts. A low SMI and SMD were both associated with age (p<0.05 and p<0.01, respectively) on univariate analysis. On multivariate analysis, a low SMD was independently associated with age (OR 2.38 (1.34-4.22), p=0.003) and mGPS (OR 2.10 (1.20-3.68), p=0.01). Conclusions: In conclusion, the prevalence of a low SMI and low SMD was similar in non-cancer and cancer cohorts in our institution.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Maguire, Donogh and Horgan, Professor Paul and Dolan, Dr Ross and McMillan, Professor Donald and Laird, Dr Barry and McGovern, Mr Josh
• Authors: McGovern, J., Dolan, R. D., Maguire, D., Horgan, P., Laird, B. J., and McMillan, D. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Frailty, Sarcopenia and Falls
• Publisher: Hylonome Publications
• ISSN: 2459-4148
• ISSN (Online): 2459-4148
• Published Online: 01 September 2022
• Copyright Holders: Copyright © 2022 the author(s)
• First Published: First published in Journal of Frailty, Sarcopenia and Falls
• Publisher Policy: Reproduced under a Creative Commons license