Long-term persistence of Opisthorchis viverrini antigen in urine: a prospective study in northeast Thailand

Worasith, C. et al. (2023) Long-term persistence of Opisthorchis viverrini antigen in urine: a prospective study in northeast Thailand. American Journal of Tropical Medicine and Hygiene, 108(2), pp. 356-358. (doi: 10.4269/ajtmh.22-0478) (PMID:36572008)

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Abstract

Antigen detected in urine for the diagnosis of opisthorchiasis has a low daily variation; however, the longer term variability in antigen concentrations is unknown. In this study, we prospectively monitored Opisthorchis viverrini antigen concentrations for 30 consecutive days and at subsequent monthly intervals in a cohort of opisthorchiasis-positive individuals. On the basis of the monoclonal antibody–based ELISA, the profiles of antigen-positive rate and antigen concentration exhibited no significant change over 30 days with a mean proportion positive of 87.1% (range 73.7%–100%), and the average antigen concentration was 29.7 ± 2.2 ng/mL (mean ± SE). The urine antigen concentration at baseline was similar to the subsequent measurements at 2, 4, 6, and 10 months in the follow-up study (P > 0.05). The consistency and low daily and long-term fluctuation of O. viverrini antigen in urine demonstrates the reliability of urine assay for diagnosis of opisthorchiasis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Crellen, Dr Thomas
Authors: Worasith, C., Wongphutorn, P., Kopolrat, K. Y., Homwong, C., Techasen, A., Thanan, R., Wangboon, C., Eamudomkarn, C., Sithithaworn, J., Crellen, T., and Sithithaworn, P.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:American Journal of Tropical Medicine and Hygiene
Publisher:American Society of Tropical Medicine and Hygiene
ISSN:0002-9637
ISSN (Online):1476-1645
Published Online:26 December 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in American Journal of Tropical Medicine and Hygiene 108(2): 356-358
Publisher Policy:Reproduced under a Creative Commons licence

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