Impact of the flavonoid quercetin on β-amyloid aggregation revealed by intrinsic fluorescence

Alghamdi, A., Birch, D. J.S., Vyshemirsky, V. and Rolinski, O. J. (2022) Impact of the flavonoid quercetin on β-amyloid aggregation revealed by intrinsic fluorescence. Journal of Physical Chemistry B, 126(38), pp. 7229-7237. (doi: 10.1021/acs.jpcb.2c02763) (PMID:36121408) (PMCID:PMC9527748)

Abstract

We report the effects of quercetin, a flavonoid present in the human diet, on early stage beta-amyloid (Aβ) aggregation, a seminal event in Alzheimer’s disease. Molecular level changes in Aβ arrangements are monitored by time-resolved emission spectral (TRES) measurements of the fluorescence of Aβ’s single tyrosine intrinsic fluorophore (Tyr). The results suggest that quercetin binds β-amyloid oligomers at early stages of their aggregation, which leads to the formation of modified oligomers and hinders the creation of β-sheet structures, potentially preventing the onset of Alzheimer’s disease.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Vyshemirsky, Dr Vladislav
• Authors: Alghamdi, A., Birch, D. J.S., Vyshemirsky, V., and Rolinski, O. J.
• College/School: College of Science and Engineering > School of Mathematics and Statistics > Statistics
• Journal Name: Journal of Physical Chemistry B
• Publisher: American Chemical Society
• ISSN: 1520-6106
• ISSN (Online): 1520-5207
• Published Online: 19 September 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Journal of Physical Chemistry B 126(38): 7229-7237
• Publisher Policy: Reproduced under a Creative Commons License