Simola, J., Siebenhühner, F., Myrov, V., Kantojärvi, K., Paunio, T., Palva, J. M. , Brattico, E. and Palva, S. (2022) Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations. iScience, 25(9), 104985. (doi: 10.1016/j.isci.2022.104985) (PMID:36093050) (PMCID:PMC9460523)
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Abstract
Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol- -methyltransferase ( ) Val Met and brain-derived neurotrophic factor ( ) Val Met. Both and polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that and genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that and polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the Jane and Aatos Erkko Foundation, by the Academy of Finland (SA 1266402, 1267030 to S.P., SA 1266745, 1296304 to J.M.P., and SA 1294761 to J.S.). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Palva, Professor Satu and Palva, Professor Matias |
| Authors: | Simola, J., Siebenhühner, F., Myrov, V., Kantojärvi, K., Paunio, T., Palva, J. M., Brattico, E., and Palva, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | iScience |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 2589-0042 |
| ISSN (Online): | 2589-0042 |
| Published Online: | 18 August 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in iScience 25(9): 104985 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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