Frozen shoulder

Millar, N. L. et al. (2022) Frozen shoulder. Nature Reviews Disease Primers, 8, 59. (doi: 10.1038/s41572-022-00386-2) (PMID:36075904)

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Frozen shoulder is a common debilitating disorder characterized by shoulder pain and progressive loss of shoulder movement. Frozen shoulder is frequently associated with other systemic conditions or occurs following periods of immobilization, and has a protracted clinical course, which can be frustrating for patients as well as health-care professionals. Frozen shoulder is characterized by fibroproliferative tissue fibrosis, whereby fibroblasts, producing predominantly type I and type III collagen, transform into myofibroblasts (a smooth muscle phenotype), which is accompanied by inflammation, neoangiogenesis and neoinnervation, resulting in shoulder capsular fibrotic contractures and the associated clinical stiffness. Diagnosis is heavily based on physical examination and can be difficult depending on the stage of disease or if concomitant shoulder pathology is present. Management consists of physiotherapy, therapeutic modalities such as steroid injections, anti-inflammatory medications, hydrodilation and surgical interventions; however, their effectiveness remains unclear. Facilitating translational science should aid in development of novel therapies to improve outcomes among individuals with this debilitating condition.

Item Type:Articles
Keywords:Physical Therapy Modalities, Fibrosis, Humans, Bursitis - surgery - therapy
Glasgow Author(s) Enlighten ID:Akbar, Mr Moeed and Millar, Professor Neal
Authors: Millar, N. L., Meakins, A., Struyf, F., Willmore, E., Campbell, A. L., Kirwan, P. D., Akbar, M., Moore, L., Ronquillo, J. C., Murrell, G. A. C., and Rodeo, S. A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:Nature Reviews Disease Primers
Publisher:Nature Publishing Group
ISSN (Online):2056-676X
Published Online:08 September 2022
Copyright Holders:Copyright © Springer Nature Limited 2022
First Published:First published in Nature Reviews Disease Primers 8: 59
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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