Factor VIII companion diagnostic for haemophilia

Hu, C. , Annese, V. F. , Giagkoulovits, C. , Barrett, M. P. and Cumming, D. R. S. (2022) Factor VIII companion diagnostic for haemophilia. Frontiers in Bioengineering and Biotechnology, 10, 1006600. (doi: 10.3389/fbioe.2022.1006600) (PMID:36277382) (PMCID:PMC9579283)

[img] Text
280107.pdf - Published Version
Available under License Creative Commons Attribution.



Haemophilia is predominantly an inherited disorder that impairs the body’s ability to make blood clots, a process needed to stop bleeding. The condition of this disease is complex to manage, but many patients do so through home therapy and often only see their core multidisciplinary healthcare team annually. There is an increasing need for patients to be able to monitor their condition efficiently at home while staying connected with their healthcare team. As a consequence, a low-cost handheld self-monitoring solution for clotting factor is required. Here we have demonstrated a suitable one-step Factor VIII companion diagnostic sensing approach based on a chromogenic assay for haemophilia A. The results show comparable performance to the gold standard method. Our approach is able to deliver accurate cost-effective results in under 5 min from undiluted human plasma. It has the potential to be able to reduce the human and monetary costs of over- or under-medication for haemophiliacs.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cumming, Professor David and Hu, Dr Chunxiao and Annese, Dr Valerio and Barrett, Professor Michael and Giagkoulovits, Dr Christos
Authors: Hu, C., Annese, V. F., Giagkoulovits, C., Barrett, M. P., and Cumming, D. R. S.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Biomedical Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Frontiers in Bioengineering and Biotechnology
ISSN (Online):2296-4185
Published Online:05 October 2022
Copyright Holders:Copyright © 2022 Hu, Annese, Giagkoulovits, Barrett and Cumming
First Published:First published in Frontiers in Bioengineering and Biotechnology 10:1006600
Publisher Policy:Reproduced under a Creative Commons license
Data DOI:10.5525/gla.researchdata.1242

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190623The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - Electronics & Nanoscale Engineering
170547The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/ZIII - Parasitology