Garimella, P. S., Du Toit, C. , Le, N. N. and Padmanabhan, S. (2023) A genomic deep field view of hypertension. Kidney International, 103(1), pp. 42-52. (doi: 10.1016/j.kint.2022.09.029) (PMID:36377113)
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Abstract
Blood pressure is regulated by a complex neurohumoral system including the renin–angiotensin–aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic nervous system, and the immune system. This review charts the evolution of our understanding of the genomic basis of hypertension at increasing resolution over the last five decades from monogenic causes to polygenic associations. spanning approximately 30 monogenic rare variants and >1500 single nucleotide variants. Unexpected early wins from blood pressure genomics include deepening of our understanding of the complex causation of hypertension; refinement of causal estimates bi-directionally between blood pressure, risk factors and outcomes through mendelian randomisation; risk stratification using polygenic risk scores; and opportunities for precision medicine and drug repurposing.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Padmanabhan, Professor Sandosh and LE, NHU NGOC and Du Toit, Ms Clea |
| Authors: | Garimella, P. S., Du Toit, C., Le, N. N., and Padmanabhan, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences |
| Journal Name: | Kidney International |
| Publisher: | Elsevier |
| ISSN: | 0085-2538 |
| ISSN (Online): | 1523-1755 |
| Published Online: | 29 October 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Kidney International 103(1): 42-52 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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