Updates on androgen replacement therapy and lower urinary tract symptoms: a narrative review

Al-Zoubi, R. M., Alwani, M., Aboumarzouk, O. M. , Elaarag, M., Al-Qudimat, A. R., Ojha, L. and Yassin, A. (2022) Updates on androgen replacement therapy and lower urinary tract symptoms: a narrative review. Aging Male, 25(1), pp. 234-241. (doi: 10.1080/13685538.2022.2118253) (PMID:36066424)

Abstract

Lower urinary tract symptoms (LUTS) are caused by higher tension at the bladder neck level (due to fibrosis or stiffness) or benign prostatic hyperplasia, which causes static obstruction of the bladder outlet. Both forms cause a group of symptoms such as hesitancy, intermittency, weak stream, nocturia, urine frequency, and urgency. Additionally, LUTS (obstructive or irritative symptoms) are common in elderly men with hypogonadism, identified as the reduced testes capability in producing sex steroids and sperm, and are categorized as testosterone deficiency. Even though the mode of action (MoA) of testosterone therapy (TTh) on hypogonadal men needs more researched and understanding, the effectiveness of TTh in the development of male genital organs has been reported in several studies. This review shows the latest updates of TTh in LUTS including potential adverse effects, advantages, and disadvantages.

• Item Type: Articles
• Keywords: Semen, prostatic hyperplasia - complications, androgen, aged, male, BPH, TRT, testosterone - therapeutic use, hormone replacement therapy, lower urinary tract symptoms - etiology, humans, hypogonadism, LUTS.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Aboumarzouk, Mr Omar
• Authors: Al-Zoubi, R. M., Alwani, M., Aboumarzouk, O. M., Elaarag, M., Al-Qudimat, A. R., Ojha, L., and Yassin, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Aging Male
• Publisher: Taylor and Francis
• ISSN: 1368-5538
• ISSN (Online): 1473-0790
• Published Online: 06 September 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Aging Male 25(1):234-241
• Publisher Policy: Reproduced under a Creative Commons licence