A community approach to the cancer-variant-interpretation bottleneck

Krysiak, K. et al. (2022) A community approach to the cancer-variant-interpretation bottleneck. Nature Cancer, 3(5), pp. 522-525. (doi: 10.1038/s43018-022-00379-w) (PMID:35624339)

Abstract

As guidelines, therapies and literature on cancer variants expand, the lack of consensus variant interpretations impedes clinical applications. CIViC is a public-domain, crowd-sourced and adaptable knowledgebase of evidence for the clinical interpretation of variants in cancer, designed to reduce barriers to knowledge sharing and alleviate the variant-interpretation bottleneck.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lever, Dr Jake
• Authors: Krysiak, K., Danos, A. M., Kiwala, S., McMichael, J. F., Coffman, A. C., Barnell, E. K., Sheta, L., Saliba, J., Grisdale, C. J., Kujan, L., Pema, S., Lever, J., Spies, N. C., Chiorean, A., Rieke, D. T., Clark, K. A., Jani, P., Takahashi, H., Horak, P., Ritter, D. I., Zhou, X., Ainscough, B. J., Delong, S., Lamping, M., Marr, A. R., Li, B. V., Lin, W.-H., Terraf, P., Salama, Y., Campbell, K. M., Farncombe, K. M., Ji, J., Zhao, X., Xu, X., Kanagal-Shamanna, R., Cotto, K. C., Skidmore, Z. L., Walker, J. R., Zhang, J., Milosavljevic, A., Patel, R. Y., Giles, R. H., Kim, R. H., Schriml, L. M., Mardis, E. R., Jones, S. J. M., Raca, G., Rao, S., Madhavan, S., Wagner, A. H., Griffith, O. L., and Griffith, M.
• College/School: College of Science and Engineering > School of Computing Science
• Journal Name: Nature Cancer
• Publisher: Nature Research
• ISSN: 2662-1347
• ISSN (Online): 2662-1347
• Published Online: 27 May 2022
• Copyright Holders: Copyright © 2022 Springer Nature
• First Published: First published in Nature Cancer
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher 3(5):522-525