Hastie, C. E. et al. (2022) Outcomes among confirmed cases and a matched comparison group in the Long-COVID in Scotland Study. Nature Communications, 13, 5663. (doi: 10.1038/s41467-022-33415-5) (PMID:36224173) (PMCID:PMC9556711)
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Abstract
With increasing numbers infected by SARS-CoV-2, understanding long-COVID is essential to inform health and social care support. A Scottish population cohort of 33,281 laboratory-confirmed SARS-CoV-2 infections and 62,957 never-infected individuals were followed-up via 6, 12 and 18-month questionnaires and linkage to hospitalization and death records. Of the 31,486 symptomatic infections,1,856 (6%) had not recovered and 13,350 (42%) only partially. No recovery was associated with hospitalized infection, age, female sex, deprivation, respiratory disease, depression and multimorbidity. Previous symptomatic infection was associated with poorer quality of life, impairment across all daily activities and 24 persistent symptoms including breathlessness (OR 3.43, 95% CI 3.29–3.58), palpitations (OR 2.51, OR 2.36–2.66), chest pain (OR 2.09, 95% CI 1.96–2.23), and confusion (OR 2.92, 95% CI 2.78–3.07). Asymptomatic infection was not associated with adverse outcomes. Vaccination was associated with reduced risk of seven symptoms. Here we describe the nature of long-COVID and the factors associated with it.
| Item Type: | Articles |
|---|---|
| Additional Information: | Long-CISS was funded by the Chief Scientist Office (ref. COV/LTE/20/06) and Public Health Scotland. NLM is supported by a Chair Award (CH/F/21/90010), a Programme Grant (RG/20/10/34966) and a Research Excellence Award (RE/18/5/34216) from the British Heart Foundation. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Blane, Dr David and Hastie, Dr Claire and Browne, Dr Susan and Ibbotson, Dr Tracy and Winter, Dr Andrew and Scott, Dr Janet and Pell, Professor Jill and Lowe, Dr David and O'Donnell, Professor Kate |
| Authors: | Hastie, C. E., Lowe, D. J., McAuley, A., Winter, A. J., Mills, N. L., Black, C., Scott, J. T., O'Donnell, C. A., Blane, D. N., Browne, S., Ibbotson, T. R., and Pell, J. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Nature Communications |
| Publisher: | Nature Research |
| ISSN: | 2041-1723 |
| ISSN (Online): | 2041-1723 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Nature Communications 13: 5663 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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