The clinical value of C-reactive protein and its association with tumour location in patients undergoing curative surgery for colorectal cancer – a ScotScan collaborative study

Fuglestad, A. J., Meltzer, S., Ree, A. H., McMillan, D. C. , Park, J. H. and Kersten, C. (2022) The clinical value of C-reactive protein and its association with tumour location in patients undergoing curative surgery for colorectal cancer – a ScotScan collaborative study. Acta Oncologica, 61(10), pp. 1248-1255. (doi: 10.1080/0284186X.2022.2117572) (PMID:36068730)

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Abstract

Introduction: The presence of preoperative systemic inflammatory response (SIR) is an established negative prognostic factor for patients diagnosed with colorectal cancer (CRC). C-reactive protein (CRP) is known to be implicated in detrimental immune responses. The biological differences between right-sided and left-sided CRC are gaining increasing attention. Our aim was to analyse the prognostic value of CRP and explore the association between tumour location and SIR. Material and methods: A total of 2059 patients treated for stage I–III CRC, identified from the prospectively sampled ScotScan Collaborative dataset, were included. The clinical and prognostic value of five CRP levels (<10/11–30/31–60/61–100/>100 mg/l) were examined. Additionally, the relationship between SIR and tumour location was explored. Results: Increasing levels of CRP were associated with impaired overall and cancer-specific outcome. Presence of SIR was independently associated with right-sided tumour location (p<0.001). However, the impact of SIR on cancer-specific survival (CSS) was greater for left-sided tumour location, even when adjusted for other clinicopathological factors. Conclusions: This study confirms CRP as a routinely available, valid, and clinically relevant strong prognostic marker of SIR in CRC patients. Right-sided tumours were more often associated with SIR, but the prognostic impact was stronger in left-sided tumours.

Item Type:Articles
Additional Information:This work was supported by the South-Eastern Norway Regional Health Authority [grant 2019109] (to A.H.R).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Park, Mr James and McMillan, Professor Donald
Authors: Fuglestad, A. J., Meltzer, S., Ree, A. H., McMillan, D. C., Park, J. H., and Kersten, C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Acta Oncologica
Publisher:Taylor & Francis
ISSN:0284-186X
ISSN (Online):1651-226X
Published Online:06 September 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Acta Oncologica 61(10): 1248-1255
Publisher Policy:Reproduced under a Creative Commons License

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