Fuglestad, A. J., Meltzer, S., Ree, A. H., McMillan, D. C. , Park, J. H. and Kersten, C. (2022) The clinical value of C-reactive protein and its association with tumour location in patients undergoing curative surgery for colorectal cancer – a ScotScan collaborative study. Acta Oncologica, 61(10), pp. 1248-1255. (doi: 10.1080/0284186X.2022.2117572) (PMID:36068730)
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Abstract
Introduction: The presence of preoperative systemic inflammatory response (SIR) is an established negative prognostic factor for patients diagnosed with colorectal cancer (CRC). C-reactive protein (CRP) is known to be implicated in detrimental immune responses. The biological differences between right-sided and left-sided CRC are gaining increasing attention. Our aim was to analyse the prognostic value of CRP and explore the association between tumour location and SIR. Material and methods: A total of 2059 patients treated for stage I–III CRC, identified from the prospectively sampled ScotScan Collaborative dataset, were included. The clinical and prognostic value of five CRP levels (<10/11–30/31–60/61–100/>100 mg/l) were examined. Additionally, the relationship between SIR and tumour location was explored. Results: Increasing levels of CRP were associated with impaired overall and cancer-specific outcome. Presence of SIR was independently associated with right-sided tumour location (p<0.001). However, the impact of SIR on cancer-specific survival (CSS) was greater for left-sided tumour location, even when adjusted for other clinicopathological factors. Conclusions: This study confirms CRP as a routinely available, valid, and clinically relevant strong prognostic marker of SIR in CRC patients. Right-sided tumours were more often associated with SIR, but the prognostic impact was stronger in left-sided tumours.
Item Type: | Articles |
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Additional Information: | This work was supported by the South-Eastern Norway Regional Health Authority [grant 2019109] (to A.H.R). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Park, Mr James and McMillan, Professor Donald |
Authors: | Fuglestad, A. J., Meltzer, S., Ree, A. H., McMillan, D. C., Park, J. H., and Kersten, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Acta Oncologica |
Publisher: | Taylor & Francis |
ISSN: | 0284-186X |
ISSN (Online): | 1651-226X |
Published Online: | 06 September 2022 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Acta Oncologica 61(10): 1248-1255 |
Publisher Policy: | Reproduced under a Creative Commons License |
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