Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda

Atim, S. A. et al. (2022) Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda. Journal of Infection, 85(6), pp. 693-701. (doi: 10.1016/j.jinf.2022.09.007) (PMID:36108783) (PMCID:PMC9731351)

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Background: Crimean-Congo Haemorrhagic Fever (CCHF) is an emerging human-health threat causing sporadic outbreaks in livestock farming communities. However, the full extent and the risks associated with exposure of such communities has not previously been well-described. Methods: We collected blood samples from 800 humans, 666 cattle, 549 goats and 32 dogs in districts within and outside Ugandan cattle corridor in a cross-sectional survey, and tested for CCHFV-specific IgG antibodies using Enzyme-Linked Immunosorbent Assays. Sociodemographic and epidemiological data were recorded using structured questionnaire. Ticks were collected to identify circulating nairoviruses by metagenomic sequencing. Results: CCHFV seropositivity was in 221/800 (27·6%) in humans, 612/666 (91·8%) in cattle, 413/549 (75·2%) in goats and 18/32 (56·2%) in dogs. Human seropositivity was associated with livestock farming (AOR=5·68, p<0·0001), age (AOR=2·99, p=0·002) and collecting/eating engorged ticks (AOR=2·13, p=0·004). In animals, seropositivity was higher in cattle versus goats (AOR=2·58, p<0·0001), female sex (AOR=2·13, p=0·002) and heavy tick infestation (>50 ticks: AOR=3·52, p=0·004). CCHFV was identified in multiple tick pools of Rhipicephalus appendiculatus. Interpretation: The very high CCHF seropositivity especially among livestock farmers and multiple regional risk factors associated exposures, including collecting/eating engorged ticks previously unrecognised, highlights need for further surveillance and sensitisation and control policies against the disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Thomson, Professor Emma and Johnson, Dr Paul and Niebel, Dr Marc and Masembe, Dr Charles and Shepherd, Dr James and Ashraf, Dr Shirin and Atim, Ms Stella
Authors: Atim, S. A., Ashraf, S., Belij-Rammerstorfer, S., Ademun, A. R., Vudriko, P., Nakayiki, T., Niebel, M., Shepherd, J., Balinandi, S., Nakanjako, G., Abaasa, A., Johnson, P. C.D., Odongo, S., Esau, M., Bahati, M., Kaleebu, P., Lutwama, J. J., Masembe, C., Lambe, T., Thomson, E. C., and Tweyongyere, R.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Journal of Infection
ISSN (Online):1532-2742
Published Online:13 September 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of Infection 85(6): 693-701
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
169538T-cell mediated evolution of hepatitis C virus during acute infectionEmma ThomsonWellcome Trust (WELLCOTR)102789/Z/13/ZIII-MRC-GU Centre for Virus Research
172630008Arthropod-borne infections and emerging virus infections in high risk areas (Programme 4)Emma ThomsonMedical Research Council (MRC)MC_UU_12014/8III - Centre for Virus Research