Antoniou-Kourounioti, R. and Howard, M. (2017) Quantitative environmentally triggered switching between stable epigenetic states. In: Ringrose, L. (ed.) Epigenetics and Systems Biology. Series: Translational Epigenetics. Academic Press, pp. 169-187. ISBN 9780128030752 (doi: 10.1016/B978-0-12-803075-2.00008-8)
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Abstract
Cold temperature is an environmental signal that can quantitatively determine the expression levels of the plant flowering regulator, Flowering Locus C (FLC), weeks or months after the cold signal itself has gone, a classic example of quantitative epigenetics. A close collaboration between mathematical modelers and biologists has significantly elucidated the mechanisms behind this long-term quantitative epigenetic regulation. This work has demonstrated that cold memory is held independently at each FLC gene copy in an all-or-nothing digital fashion. This memory is likely stored, at least in part, by high levels of histone H3 lysine 27 trimethylation (H3K27me3), a silencing histone modification. The fraction of digitally ON versus OFF loci gives the graded FLC levels observed at a population level. Modeling has also predicted the need for antagonism between activating and silencing histone modifications, a feature which has recently been confirmed experimentally.
| Item Type: | Book Sections |
|---|---|
| Status: | Published |
| Glasgow Author(s) Enlighten ID: | Antoniou Kourounioti, Dr Rea Laila |
| Authors: | Antoniou-Kourounioti, R., and Howard, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Epigenetics and Systems Biology |
| Publisher: | Academic Press |
| ISBN: | 9780128030752 |
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