Johansson, J.U., Woodling, N.S. , Shi, J. and Andreasson, K.I. (2015) Inflammatory cyclooxygenase activity and PGE2 signaling in models of alzheimer’s disease. Current Immunology Reviews, 11(2), pp. 125-131. (doi: 10.2174/1573395511666150707181414) (PMID:28413375) (PMCID:PMC5384338)
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Abstract
The inflammatory response is a fundamental driving force in the pathogenesis of Alzheimer’s disease (AD). In the setting of accumulating immunogenic Aß peptide assemblies, microglia, the innate immune cells of the brain, generate a non-resolving immune response and fail to adequately clear accumulating Aß peptides, accelerating neuronal and synaptic injury. Pathological, biomarker, and imaging studies point to a prominent role of the innate immune response in AD development, and the molecular components of this response are beginning to be unraveled. The inflammatory cyclooxygenase-PGE2 pathway is implicated in pre-clinical development of AD, both in epidemiology of normal aging populations and in transgenic mouse models of Familial AD. The cyclooxygenase-PGE2 pathway modulates the inflammatory response to accumulating Aß peptides through actions of specific E-prostanoid G-protein coupled receptors.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Woodling, Dr Nathan |
| Authors: | Johansson, J.U., Woodling, N.S., Shi, J., and Andreasson, K.I. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Current Immunology Reviews |
| Publisher: | Bentham Science Publishers |
| ISSN: | 1573-3955 |
| ISSN (Online): | 1875-631X |
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