Efficacy and safety of dapagliflozin in heart failure with mildly reduced or preserved ejection fraction according to age: the DELIVER trial

Peikert, A. et al. (2022) Efficacy and safety of dapagliflozin in heart failure with mildly reduced or preserved ejection fraction according to age: the DELIVER trial. Circulation: Heart Failure, 15(10), pp. 934-943. (doi: 10.1161/CIRCHEARTFAILURE.122.010080) (PMID:36029467)

Abstract

Background: The prevalence of heart failure (HF) with mildly reduced or preserved ejection fraction (EF) markedly increases with age, with older individuals disproportionately facing excess risk for mortality and hospitalization. Methods: The DELIVER trial (Dapagliflozin Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure) randomized patients with New York Heart Association functional class II-IV and left ventricular EF >40% to either dapagliflozin or placebo for a median follow-up period of 2.3 years. We examined efficacy and safety outcomes by age categories (<55, 55-64, 65-74 and ≥75 years) and across age as a continuous measure. Results: Among 6,263 randomized patients (aged 40-99 years, mean age 71.7 ± 9.6 years), 338 (5.4%) were <55 years, 1,007 (16.1%) were 55-64 years, 2,326 (37.1%) were 65-74 years, and 2,592 (41.4%) were ≥75 years. Dapagliflozin reduced the risk of the primary composite outcome compared with placebo in all age categories (pinteraction=0.95) and across the age spectrum as a continuous function (pinteraction=0.76). Similar benefits were observed for the components of the primary outcome, with no significant interaction between randomized treatment and age category. Adverse events occurred more frequently with increasing age, but there were no significant differences in predefined safety outcomes between patients randomized to dapagliflozin and placebo across all age categories. Conclusions: In patients with HF and mildly reduced or preserved EF enrolled in DELIVER, Dapagliflozin reduced cardiovascular death or HF events across the spectrum of age, with a consistent safety profile, including among the traditionally under-treated older segment of patients ≥75 years. Clinical Trial Registration: URL: https://www.clinicaltrials.gov Unique identifier: NCT03619213.

• Item Type: Articles
• Additional Information: The DELIVER trial was funded by AstraZeneca.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Jhund, Professor Pardeep and McMurray, Professor John
• Authors: Peikert, A., Martinez, F. A., Vaduganathan, M., Claggett, B. L., Kulac, I. J., Desai, A. S., Jhund, P. S., de Boer, R. A., DeMets, D., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S.P., Shah, S. J., Katova, T., Merkely, B., Vardeny, O., Wilderäng, U., Lindholm, D., Petersson, M., Langkilde, A.-M., McMurray, J. J.V., and Solomon, S. D.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Circulation: Heart Failure
• Publisher: American Heart Association
• ISSN: 1941-3289
• ISSN (Online): 1941-3297
• Published Online: 27 August 2022
• Copyright Holders: Copyright © 2022 American Heart Association, Inc.
• First Published: First published in Circulation: Heart Failure 15(10): 934-943
• Publisher Policy: Reproduced in accordance with the publisher copyright policy