Association of self-reported walking pace with type 2 diabetes incidence in the UK Biobank prospective cohort study

Boonpor, J., Ho, F. K., Gray, S. R. and Celis-Morales, C. A. (2022) Association of self-reported walking pace with type 2 diabetes incidence in the UK Biobank prospective cohort study. Mayo Clinic Proceedings, 97(9), pp. 1631-1640. (doi: 10.1016/j.mayocp.2022.02.028) (PMID:36058577)

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Abstract

Objective: To investigate the association between self-reported walking pace and type 2 diabetes (T2D) incidence and whether it differed by physical activity levels and walking time. Methods: There were 162,155 participants (mean age, 57.1 years; 54.9% women) from the UK Biobank prospective study, recruited between 2006 and 2010, included in the study. Walking pace was self-reported and classified as brisk, average, or slow. Total physical activity and walking time were self-reported using the International Physical Activity Questionnaire. Association between walking pace and T2D incidence and the potential moderating role of physical activity and walking time were investigated using Cox proportional hazards models. Results: The median follow-up was 7.4 (interquartile range, 6.7 to 8.2) years. There were 4442 participants in whom T2D developed during the follow-up period. In the fully adjusted model (sociodemographic factors, diet, body mass index, and physical activity), average walking pace (hazard ratio [HR], 1.28; 95% CI, 1.14 to 1.44) and slow walking pace (HR, 1.91; 95% CI, 1.62 to 2.24) were associated with a higher T2D risk compared with brisk walking among women. Among men, average walking pace (HR, 1.28; 95% CI, 1.17 to 1.40) and slow walking pace (HR, 1.73; 95% CI, 1.50 to 1.99) were also associated with higher T2D risk. Compared with slow walkers, brisk walkers have the same diabetes incidence rate 18.6 and 16.0 years later, for women and men, respectively. Conclusion: Average and slow walking pace was associated with a higher risk of incident T2D in both men and women, independent of major confounding factors. The associations were consistent across different physical activity levels and walking time.

Item Type:Articles
Additional Information:UK Biobank was established by the Wellcome Trust; Medical Research Council; Department of Health, Scottish Government; and the Northwest Regional Development Agency. It has also received funding from the Welsh Assembly Government and the British Heart Foundation. JB receives financial support from the Royal Thai Government Scholarship for her PhD.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos and Gray, Professor Stuart and Ho, Dr Frederick and Boonpor, Jirapitcha
Creator Roles:
Boonpor, J.Conceptualization, Formal analysis, Investigation, Data curation, Writing – original draft
Ho, F.Conceptualization, Writing – original draft, Writing – review and editing, Supervision
Gray, S.Conceptualization, Writing – original draft, Writing – review and editing, Supervision
Celis, C.Conceptualization, Data curation, Writing – original draft, Writing – review and editing, Supervision
Authors: Boonpor, J., Ho, F. K., Gray, S. R., and Celis-Morales, C. A.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
Journal Name:Mayo Clinic Proceedings
Publisher:Elsevier
ISSN:0025-6196
ISSN (Online):1942-5546
Published Online:01 September 2022
Copyright Holders:Copyright © 2022 Mayo Foundation for Medical Education and Research
First Published:First published in Mayo Clinic Proceedings 97(9):1631-1640
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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