Testosterone and Covid‐19: an update

Yassin, A., Sabsigh, R., Al‐Zoubi, R. M., Aboumarzouk, O. M. , Alwani, M., Nettleship, J. and Kelly, D. (2023) Testosterone and Covid‐19: an update. Reviews in Medical Virology, 33(1), e2395. (doi: 10.1002/rmv.2395) (PMID:36056748)

Abstract

There is overwhelming evidence to suggest that male gender is at a higher risk of developing more severe Covid‐19 disease and thus having poorer clinical outcomes. However, the relationship between testosterone (T) and Covid‐19 remains unclear with both protective and deleterious effects on different aspects of the disease suggested. Here, we review the current epidemiological and biological evidence on the role of testosterone in the process of SARS‐CoV‐2 infection and in mediating Covid‐19 severity, its potential to serve as a biomarker for risk stratification and discuss the possibility of T supplementation as a treatment or preventative therapy for Covid‐19.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Aboumarzouk, Mr Omar
• Authors: Yassin, A., Sabsigh, R., Al‐Zoubi, R. M., Aboumarzouk, O. M., Alwani, M., Nettleship, J., and Kelly, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Reviews in Medical Virology
• Publisher: Wiley
• ISSN: 1052-9276
• ISSN (Online): 1099-1654
• Published Online: 03 September 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Reviews in Medical Virology 33(1): e2395
• Publisher Policy: Reproduced under a Creative Commons License