The effect of self‐generated versus externally generated actions on timing, duration, and amplitude of blood oxygen level dependent response for visual feedback processing

Kavroulakis, E., van Kemenade, B. M., Arikan, B. E., Kircher, T. and Straube, B. (2022) The effect of self‐generated versus externally generated actions on timing, duration, and amplitude of blood oxygen level dependent response for visual feedback processing. Human Brain Mapping, 43(16), pp. 4954-4969. (doi: 10.1002/hbm.26053) (PMID:36056611) (PMCID:PMC9582366)

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Abstract

It has been widely assumed that internal forward models use efference copies to create predictions about the sensory consequences of our own actions. While these predictions have frequently been associated with a reduced blood oxygen level dependent (BOLD) response in sensory cortices, the timing and duration of the hemodynamic response for the processing of video feedback of self-generated (active) versus externally generated (passive) movements is poorly understood. In the present study, we tested the hypothesis that predictive mechanisms for self-generated actions lead to early and shorter neural processing compared with externally generated movements. We investigated active and passive movements using a custom-made fMRI-compatible movement device. Visual video feedback of the active and passive movements was presented in real time or with variable delays. Participants had to judge whether the feedback was delayed. Timing and duration of BOLD impulse response was calculated using a first (temporal derivative [TD]) and second-order (dispersion derivative [DD]) Taylor approximation. Our reanalysis confirmed our previous finding of reduced BOLD response for active compared to passive movements. Moreover, we found positive effects of the TD and DD in the supplementary motor area, cerebellum, visual cortices, and subcortical structures, indicating earlier and shorter hemodynamic responses for active compared to passive movements. Furthermore, earlier activation in the putamen for active compared to passive conditions was associated with reduced delay detection performance. These findings indicate that efference copy-based predictive mechanisms enable earlier processing of action feedback, which might have reduced the ability to detect short delays between action and feedback.

Item Type:Articles
Additional Information:This study was funded by the “Deutsche Forschungsgemeinschaft” (DFG) through the SFB/Transregio 135, “Cardinal mechanisms of perception: prediction, valuation, categorization,” and through the International Research Training Group, IRTG 1901, (“The Brain in Action-BrainAct”) and the Excellence Program of the Hessian Ministry of Higher Education, Science, Research and Art (project “The Adaptive Mind”). Benjamin Straube is supported by Deutsche Forschungsgemeinschaft grants STR 1146/15-1 and STR 1146/9-2. Bianca M. van Kemenade is supported by the Deutsche Forschungsgemeinschaft grant KE 2016/2-1.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:van Kemenade, Dr Bianca
Authors: Kavroulakis, E., van Kemenade, B. M., Arikan, B. E., Kircher, T., and Straube, B.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Human Brain Mapping
Publisher:Wiley
ISSN:1065-9471
ISSN (Online):1097-0193
Published Online:02 September 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Human Brain Mapping 43(16): 4954-4969
Publisher Policy:Reproduced under a Creative Commons License

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