Annexin A1-FPR2/ALX signaling axis regulates acute inflammation during chikungunya virus infection

de Araújo, S. et al. (2022) Annexin A1-FPR2/ALX signaling axis regulates acute inflammation during chikungunya virus infection. Cells, 11(17), 2717. (doi: 10.3390/cells11172717) (PMID:36078125) (PMCID:PMC9454528)

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Chikungunya (CHIKV) is an arthritogenic alphavirus that causes a self-limiting disease usually accompanied by joint pain and/or polyarthralgia with disabling characteristics. Immune responses developed during the acute phase of CHIKV infection determine the rate of disease progression and resolution. Annexin A1 (AnxA1) is involved in both initiating inflammation and preventing over-response, being essential for a balanced end of inflammation. In this study, we investigated the role of the AnxA1-FPR2/ALX pathway during CHIKV infection. Genetic deletion of AnxA1 or its receptor enhanced inflammatory responses driven by CHIKV. These knockout mice showed increased neutrophil accumulation and augmented tissue damage at the site of infection compared with control mice. Conversely, treatment of wild-type animals with the AnxA1 mimetic peptide (Ac2–26) reduced neutrophil accumulation, decreased local concentration of inflammatory mediators and diminished mechanical hypernociception and paw edema induced by CHIKV-infection. Alterations in viral load were mild both in genetic deletion or with treatment. Combined, our data suggest that the AnxA1-FPR2/ALX pathway is a potential therapeutic strategy to control CHIKV-induced acute inflammation and polyarthralgia.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Bonilha, Mr Caio
Creator Roles:
Bonilha, C. S.Writing – review and editing
Authors: de Araújo, S., de Melo Costa, V. R., Santos, F. M., de Sousa, C. D. F., Moreira, T. P., Gonçalves, M. R., Félix, F. B., Queiroz-Junior, C. M., Campolina-Silva, G. H., Nogueira, M. L., Sugimoto, M. A., Bonilha, C. S., Perretti, M., Souza, D. G., Costa, V. V., and Teixeira, M. M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Cells
ISSN (Online):2073-4409
Published Online:31 August 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Cells 11(17): 2717
Publisher Policy:Reproduced under a Creative Commons License

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