An outbreak of Rift Valley fever among peri-urban dairy cattle in northern Tanzania

De Glanville, W. A. et al. (2022) An outbreak of Rift Valley fever among peri-urban dairy cattle in northern Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene, 116(11), pp. 1082-1090. (doi: 10.1093/trstmh/trac076) (PMID:36040309) (PMCID:PMC9623736)

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Abstract

Background: Human and animal cases of Rift Valley fever (RVF) are typically only reported during large outbreaks. The occurrence of RVF cases that go undetected by national surveillance systems in the period between these outbreaks is considered likely. The last reported cases of RVF in Tanzania occurred during a large outbreak in 2007–2008. Methods: Samples collected between 2017 and 2019 from livestock suffering abortion across northern Tanzania were retrospectively tested for evidence of RVF virus infection using serology and reverse transcription quantitative polymerase chain reaction (RT-qPCR). Results: A total of 14 RVF-associated cattle abortions were identified among dairy cattle in a peri-urban area surrounding the town of Moshi. RVF cases occurred from May to August 2018 and were considered to represent an undetected, small-scale RVF outbreak. Milk samples from 3 of 14 cases (21%) were found to be RT-qPCR positive. Genotyping revealed circulation of RVF viruses from two distinct lineages. Conclusions: RVF outbreaks can occur more often in endemic settings than would be expected on the basis of detection by national surveillance. The occurrence of RVF cases among peri-urban dairy cattle and evidence for viral shedding in milk, also highlights potentially emerging risks for RVF associated with increasing urban and peri-urban livestock populations.

Item Type:Articles
Additional Information:This research was supported by the Supporting Evidence Based Interventions project, University of Edinburgh (R83537) and the Zoonoses and Emerging Livestock Systems program (funded through the Biotechnology and Biological Sciences Research Council, Department for International Development, Economic and Social Research Council, Medical Research Council, Natural Environment Research Council and Defence Science and Technology Laboratory; BB/L018926/1, BB/L017679/1, BB/N503563/1). Additional financial support was provided through the Biotechnology and Biological Sciences Research Council (BB/J010367) and the National Institutes of Health (R01TW009237).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:De Glanville, Dr William and Halliday, Dr Jo and Lankester, Dr Felix and MMBAGA, Professor Blandina Theoph and Willett, Professor Brian and Ladbury, Georgia Ann Frances and Rostal, Melinda Kathleen and Allan, Dr Kathryn and Brennan, Dr Benjamin and Cleaveland, Professor Sarah and Carter, Mr Ryan and Claxton, Dr John and Szemiel, Dr Agnieszka
Authors: De Glanville, W. A., Allan, K., Nyarobi, J. M., Thomas, K. M., Lankester, F., Kibona, T. J., Claxton, J. R., Brennan, B., Carter, R., Crump, J. A., Halliday, J. E.B., Ladbury, G., MMBAGA, B. T., Mramba, F., Nyasebwa, O. M., Rubach, M. P., Rostal, M. K., Sanka, P., Swai, E. S., Szemiel, A. M., Willett, B. J., and Cleaveland, S.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Transactions of the Royal Society of Tropical Medicine and Hygiene
Publisher:Oxford University Press
ISSN:0035-9203
ISSN (Online):1878-3503
Published Online:30 August 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Transactions of the Royal Society of Tropical Medicine and Hygiene 116(11): 1082-1090
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190825Social, economic and environmental drivers of zoonoses in Tanzania (SEEDZ)Sarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/L018926/1Institute of Biodiversity, Animal Health and Comparative Medicine
190821Hazards associated with zoonotic enteric pathogens in emerging livestock meat pathways (HAZEL)Ruth ZadoksBiotechnology and Biological Sciences Research Council (BBSRC)BB/L017679/1Institute of Biodiversity, Animal Health and Comparative Medicine
171979Zoonoses and Emerging Livestock Systems ZELS Reducing the risk to livestock and people programme associated studentships - ZELS-ASSarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/N503563/1Institute of Biodiversity, Animal Health and Comparative Medicine
190437Impact, ecology and social determinants of bacterial zoonoses in northern TanzaniaSarah CleavelandBiotechnology and Biological Sciences Research Council (BBSRC)BB/J010367/1Institute of Biodiversity, Animal Health and Comparative Medicine