Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Lahti, J. et al. (2022) Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Molecular Psychiatry, 27(11), pp. 4419-4431. (doi: 10.1038/s41380-022-01710-8) (PMID:35974141) (PMCID:PMC9734053)

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Abstract

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

Item Type:Articles
Additional Information:Open Access funding provided by University of Helsinki including Helsinki University Central Hospital.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stott J, Professor David and Ford, Professor Ian
Authors: Lahti, J., Tuominen, S., Yang, Q., Pergola, G., Ahmad, S., Amin, N., Armstrong, N. J., Beiser, A., Bey, K., Bis, J. C., Boerwinkle, E., Bressler, J., Campbell, A., Campbell, H., Chen, Q., Corley, J., Cox, S. R., Davies, G., De Jager, P. L., Derks, E. M., Faul, J. D., Fitzpatrick, A. L., Fohner, A. E., Ford, I., Fornage, M., Gerring, Z., Grabe, H. J., Grodstein, F., Gudnason, V., Simonsick, E., Holliday, E. G., Joshi, P. K., Kajantie, E., Kaprio, J., Karell, P., Kleineidam, L., Knol, M. J., Kochan, N. A., Kwok, J. B., Leber, M., Lam, M., Lee, T., Li, S., Loukola, A., Luck, T., Marioni, R. E., Mather, K. A., Medland, S., Mirza, S. S., Nalls, M. A., Nho, K., O'Donnell, A., Oldmeadow, C., Painter, J., Pattie, A., Reppermund, S., Risacher, S. L., Rose, R. J., Sadashivaiah, V., Scholz, M., Satizabal, C. L., Schofield, P. W., Schraut, K. E., Scott, R. J., Simino, J., Smith, A. V., Smith, J. A., Stott, D. J., Surakka, I., Teumer, A., Thalamuthu, A., Trompet, S., Turner, S. T., van der Lee, S. J., Villringer, A., Völker, U., Wilson, R. S., Wittfeld, K., Vuoksimaa, E., Xia, R., Yaffe, K., Yu, L., Zare, H., Zhao, W., Ames, D., Attia, J., Bennett, D. A., Brodaty, H., Chasman, D. I., Goldman, A. L., Hayward, C., Ikram, M. A., Jukema, J. W., Kardia, S. L.R., Lencz, T., Loeffler, M., Mattay, V. S., Palotie, A., Psaty, B. M., Ramirez, A., Ridker, P. M., Riedel-Heller, S. G., Sachdev, P. S., Saykin, A. J., Scherer, M., Schofield, P. R., Sidney, S., Starr, J. M., Trollor, J., Ulrich, W., Wagner, M., Weir, D. R., Wilson, J. F., Wright, M. J., Weinberger, D. R., Debette, S., Eriksson, J. G., Mosley, T. H., Launer, L. J., van Duijn, C. M., Deary, I. J., Seshadri, S., and Räikkönen, K.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
Journal Name:Molecular Psychiatry
Publisher:Springer Nature
ISSN:1359-4184
ISSN (Online):1476-5578
Published Online:16 August 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Molecular Psychiatry 27(11): 4419-4431
Publisher Policy:Reproduced under a Creative Commons license

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