Ant, T. H., Mancini, M. V., McNamara, C. J., Rainey, S. M. and Sinkins, S. P. (2023) Wolbachia-virus interactions and arbovirus control through population replacement in mosquitoes. Pathogens and Global Health, 117(3), pp. 245-258. (doi: 10.1080/20477724.2022.2117939) (PMID:36205550) (PMCID:PMC10081064)
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Abstract
Following transfer into the primary arbovirus vector Aedes aegypti, several strains of the intracellular bacterium Wolbachia have been shown to inhibit the transmission of dengue, Zika, and chikungunya viruses, important human pathogens that cause significant morbidity and mortality worldwide. In addition to pathogen inhibition, many Wolbachia strains manipulate host reproduction, resulting in an invasive capacity of the bacterium in insect populations. This has led to the deployment of Wolbachia as a dengue control tool, and trials have reported significant reductions in transmission in release areas. Here, we discuss the possible mechanisms of Wolbachia-virus inhibition and the implications for long-term success of dengue control. We also consider the evidence presented in several reports that Wolbachia may cause an enhancement of replication of certain viruses under particular conditions, and conclude that these should not cause any concerns with respect to the application of Wolbachia to arbovirus control.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Rainey, Dr Stephanie and Sinkins, Professor Steven and Mancini, Dr Maria Vittoria and Ant, Dr Thomas and McNamara, Cameron |
| Authors: | Ant, T. H., Mancini, M. V., McNamara, C. J., Rainey, S. M., and Sinkins, S. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Pathogens and Global Health |
| Publisher: | Taylor and Francis |
| ISSN: | 2047-7724 |
| ISSN (Online): | 2047-7732 |
| Published Online: | 07 October 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Pathogens and Global Health 117(3): 245-258 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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