Growth and Remodelling of Right Ventricle Under Pulmonary Arterial Hypertension

Guan, D., Tian, L. and Gao, H. (2022) Growth and Remodelling of Right Ventricle Under Pulmonary Arterial Hypertension. In: 7th International Conference on Computational and Mathematical Biomedical Engineering (CMBE22), Milan, Italy, 27-29 Jun 2022,

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Pulmonary arterial hypertension (PAH) is a fatal and rapidly progressive disease, and right ventricular failure is the main cause of death in patients with PAH. This study aims to determine the mechanical cues that can trigger the growth and remodelling of the heart. To this end, two bi-ventricular models of a control rat heart and a diseased rat heart with PAH are reconstructed, respectively, and then the growth amount is estimated by warping the PAH heart to the control heart. Finally, correlation analysis between mechanical cues (stress and strain) and growth tensors demonstrates principal strain may be a triggering cue for myocardial growth under PAH.

Item Type:Conference Proceedings
Glasgow Author(s) Enlighten ID:Guan, Mr Debao and Gao, Dr Hao
Authors: Guan, D., Tian, L., and Gao, H.
Subjects:Q Science > QA Mathematics
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Copyright Holders:Copyright © 2022 The Authors
Publisher Policy:Reproduced with the permission of the author
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
308255The SofTMech Statistical Emulation and Translation HubDirk HusmeierEngineering and Physical Sciences Research Council (EPSRC)EP/T017899/1M&S - Statistics
303232EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI (SofTMech-MP)Xiaoyu LuoEngineering and Physical Sciences Research Council (EPSRC)EP/S030875/1M&S - Mathematics