Growth and Remodelling of Right Ventricle Under Pulmonary Arterial Hypertension

Guan, D., Tian, L. and Gao, H. (2022) Growth and Remodelling of Right Ventricle Under Pulmonary Arterial Hypertension. In: 7th International Conference on Computational and Mathematical Biomedical Engineering (CMBE22), Milan, Italy, 27-29 Jun 2022,

Abstract

Pulmonary arterial hypertension (PAH) is a fatal and rapidly progressive disease, and right ventricular failure is the main cause of death in patients with PAH. This study aims to determine the mechanical cues that can trigger the growth and remodelling of the heart. To this end, two bi-ventricular models of a control rat heart and a diseased rat heart with PAH are reconstructed, respectively, and then the growth amount is estimated by warping the PAH heart to the control heart. Finally, correlation analysis between mechanical cues (stress and strain) and growth tensors demonstrates principal strain may be a triggering cue for myocardial growth under PAH.

• Item Type: Conference Proceedings
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Guan, Mr Debao and Gao, Dr Hao
• Authors: Guan, D., Tian, L., and Gao, H.
• Subjects: Q Science > QA Mathematics
• College/School: College of Science and Engineering > School of Mathematics and Statistics > Mathematics
• Copyright Holders: Copyright © 2022 The Authors
• Publisher Policy: Reproduced with the permission of the author

Related URLs

• Organisation

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
308255		The SofTMech Statistical Emulation and Translation Hub	Dirk Husmeier	Engineering and Physical Sciences Research Council (EPSRC)	EP/T017899/1	M&S - Statistics
303232		EPSRC Centre for Multiscale soft tissue mechanics with MIT and POLIMI (SofTMech-MP)	Xiaoyu Luo	Engineering and Physical Sciences Research Council (EPSRC)	EP/S030875/1	M&S - Mathematics