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Short Report: Choline plasma levels are related to Nrf2 transcriptional expression in chronic kidney disease?

Mafra, D., Cardozo, L., Ribeiro-Alves, M., Bergman, P., Shiels, P. G. and Stenvinkel, P. (2022) Short Report: Choline plasma levels are related to Nrf2 transcriptional expression in chronic kidney disease? Clinical Nutrition ESPEN, 50, pp. 318-321. (doi: 10.1016/j.clnesp.2022.06.008) (PMID:35871941)

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Abstract

Background and Aims: Choline is an amine osmolyte with antioxidant potential. A limited number of studies have implied that choline modulates the nuclear factor-erythroid 2-related factor 2 (Nrf 2) pathway, a major cytoprotectant system. However, there are no data regarding such an interaction in patients with chronic kidney disease (CKD). This cross-sectional pilot study therefore aimed to evaluate the possible relationship between choline plasma levels and transcriptional expression of Nrf2 in patients with CKD on hemodialysis (HD). Methods: This study was performed in 24 HD patients [54 ± 10 years, 14 men, BMI 26.4 ± 4.5 kg/m2]. Choline plasma levels were measured by LC-MS/MS. Nrf2 mRNA expression was measured by real-time quantitative polymerase chain reaction (rt-PCR) in isolated peripheral blood mononuclear cells (PBMC). Results: We used Pearson's correlation (rho) to determine the correlations with Nrf 2 expression and observed a positive correlation between choline plasma levels and Nrf2 (rho = 0.56, P = 0.004). Conclusions: This finding suggests that choline may play a role in Nrf2 expression in CKD.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul
Authors: Mafra, D., Cardozo, L., Ribeiro-Alves, M., Bergman, P., Shiels, P. G., and Stenvinkel, P.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Clinical Nutrition ESPEN
Publisher:Elsevier
ISSN:2405-4577
ISSN (Online):2405-4577
Published Online:15 June 2022
Copyright Holders:Copyright © 2022 European Society for Clinical Nutrition and Metabolism
First Published:First published in Clinical Nutrition ESPEN 50: 318-321
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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