Mitochondrial control of inflammation

Marchi, S., Guilbaud, E., Tait, S. W.G. , Yamazaki, T. and Galluzzi, L. (2023) Mitochondrial control of inflammation. Nature Reviews Immunology, 23(3), pp. 159-173. (doi: 10.1038/s41577-022-00760-x) (PMID:35879417) (PMCID:PMC9310369)

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Numerous mitochondrial constituents and metabolic products can function as damage-associated molecular patterns (DAMPs) and promote inflammation when released into the cytosol or extracellular milieu. Several safeguards are normally in place to prevent mitochondria from eliciting detrimental inflammatory reactions, including the autophagic disposal of permeabilized mitochondria. However, when the homeostatic capacity of such systems is exceeded or when such systems are defective, inflammatory reactions elicited by mitochondria can become pathogenic and contribute to the aetiology of human disorders linked to autoreactivity. In addition, inefficient inflammatory pathways induced by mitochondrial DAMPs can be pathogenic as they enable the establishment or progression of infectious and neoplastic disorders. Here we discuss the molecular mechanisms through which mitochondria control inflammatory responses, the cellular pathways that are in place to control mitochondria-driven inflammation and the pathological consequences of dysregulated inflammatory reactions elicited by mitochondrial DAMPs.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Tait, Professor Stephen
Authors: Marchi, S., Guilbaud, E., Tait, S. W.G., Yamazaki, T., and Galluzzi, L.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Nature Reviews Immunology
Publisher:Nature Research
ISSN (Online):1474-1741
Published Online:25 July 2022

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