Chan, Y., Seckin, M., Johnston, B., Petrie, M. and Stewart, S. (2022) Characteristics of symptom change in men and women with different heart failure subtypes. Heart, Lung and Circulation, 31(Suppl3), S76. (doi: 10.1016/j.hlc.2022.06.074)
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Abstract
Background: We addressed the paucity of data describing the characteristics and correlates of change in self-reported symptoms among an Australian clinical cohort of men and women discharged from hospital with all subtypes of heart failure (HF). Methods: We conducted a retrospective secondary data analysis of 528 hospitalised patients with a combination of HF (with reduced, mildly reduced or preserved ejection fraction: HFrEF, HFmrEF, or HFpEF) who completed a 12-month follow-up in a multicentre disease management trial. We examined the pattern of self-reported symptoms at baseline and 12-month according to sex and HF subgroups using the Kansas City Cardiomyopathy Questionnaire. Results: The cohort comprised 302 men (57%, 71.1±11.9 years and 58% had HFrEF) and 226 women (77.2±10.7 years and 49% had HFpEF). At baseline, the predominant symptoms were shortness of breath and fatigue in both sexes. By 12 months, most HF symptom scores (except for symptom stability) were lower in both sexes irrespective of the HF subgroups. Approximately 24% and 26% of men and women, respectively, developed severe worsening symptomatic profile. Hypertension significantly correlated with 12-month worsening symptomatic profile in men (OR 2.16, 95% CI 1.07–4.352), whilst in women HF subtypes based on LVEF (HFmrEF and HFpEF) significantly correlated to worsen HF symptoms (p=0.007). Binary logistic regression analyses showed that women and men had different baseline predictors for long-term worsening HF symptoms. Conclusion: This present study found evidence of sex heterogeneity in different HF phenotypic subgroups as well as different factors that are prone to develop long-term worsening HF symptoms.
| Item Type: | Articles |
|---|---|
| Additional Information: | Part of special issue: Abstracts for the 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, 11-14 August 2022 |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Petrie, Professor Mark and SECKIN, MUZEYYEN |
| Authors: | Chan, Y., Seckin, M., Johnston, B., Petrie, M., and Stewart, S. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Heart, Lung and Circulation |
| Publisher: | Elsevier |
| ISSN: | 1443-9506 |
| ISSN (Online): | 1444-2892 |
| Published Online: | 02 August 2022 |
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