Human colonic catabolism of dietary flavan-3-ol bioactives

Di Pede, G., Mena, P., Bresciani, L., Almutairi, T. M., Del Rio, D., Clifford, M. N. and Crozier, A. (2023) Human colonic catabolism of dietary flavan-3-ol bioactives. Molecular Aspects of Medicine, 89, 101107. (doi: 10.1016/j.mam.2022.101107) (PMID:35931563)

Abstract

Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.

• Item Type: Articles
• Additional Information: T.M.A. and A.C. are grateful for support by the Distinguished Scientist Fellowship Program (DSFP) at King Saud University, Riyadh, Saudi Arabia.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crozier, Professor Alan
• Authors: Di Pede, G., Mena, P., Bresciani, L., Almutairi, T. M., Del Rio, D., Clifford, M. N., and Crozier, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Molecular Aspects of Medicine
• Publisher: Elsevier
• ISSN: 0098-2997
• ISSN (Online): 1872-9452
• Published Online: 02 August 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Molecular Aspects of Medicine 89: 101107
• Publisher Policy: Reproduced under a Creative Commons License