Exploiting a strong coupling regime of organic pentamer surface plasmon resonance based on the Otto configuration for creatinine detection

Ahmad Khushaini, M. A., Azeman, N. H., Mat Salleh, M., Tg Abdul Aziz, T. H., A Bakar, A. A., De La Rue, R. M. and Md Zain, A. R. (2022) Exploiting a strong coupling regime of organic pentamer surface plasmon resonance based on the Otto configuration for creatinine detection. Optics Express, 30(9), pp. 14478-14491. (doi: 10.1364/OE.448947) (PMID:35473189)

Abstract

The sandwiched material-analyte layer in the surface plasmon resonance (SPR)-Otto configuration emulates an optical cavity and, coupled with large optical nonlinearity material, the rate of light escaping from the system is reduced, allowing the formation of a strong coupling regime. Here, we report an organic pentamer SPR sensor using the Otto configuration to induce a strong coupling regime for creatinine detection. Prior to that, the SPR sensor chip was modified with an organic pentamer, 1,4-bis[2-(5-thiophene-2-yl)-1-benzothiopene]-2,5-dioctyloxybenzene (BOBzBT2). To improve the experimental calibration curve, a normalisation approach based on the strong coupling-induced second dip was also developed. By using this procedure, the performance of the sensor improved to 0.11 mg/dL and 0.36 mg/dL for the detection and quantification limits, respectively.

• Item Type: Articles
• Additional Information: Funding: Pusat Pengurusan Penyelidikan dan Instrumentasi (UKM-TR-016).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: De La Rue, Professor Richard
• Authors: Ahmad Khushaini, M. A., Azeman, N. H., Mat Salleh, M., Tg Abdul Aziz, T. H., A Bakar, A. A., De La Rue, R. M., and Md Zain, A. R.
• College/School: College of Science and Engineering > School of Engineering
• Journal Name: Optics Express
• Publisher: Optical Society of America
• ISSN: 1094-4087
• ISSN (Online): 1094-4087
• Published Online: 18 April 2022
• Copyright Holders: Copyright © 2022 Optica Publishing Group
• First Published: First published in Optics Express 30(9): 14478-14491
• Publisher Policy: Reproduced in accordance with the publisher copyright policy