SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity

Manali, M. et al. (2022) SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity. Journal of Infectious Diseases, (doi: 10.1093/infdis/jiac332) (PMID:35920058) (Early Online Publication)

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Abstract

Since the emergence of SARS-CoV-2, humans have been exposed to distinct SARS-CoV-2 antigens, either by infection with different variants, and/or vaccination. Population immunity is thus highly heterogeneous, but the impact of such heterogeneity on the effectiveness and breadth of the antibody-mediated response is unclear. We measured antibody-mediated neutralisation responses against SARS-CoV-2Wuhan, SARS-CoV-2α, SARS-CoV-2δ and SARS-CoV-2ο pseudoviruses using sera from patients with distinct immunological histories, including naive, vaccinated, infected with SARS-CoV-2Wuhan, SARS-CoV-2α or SARS-CoV-2δ, and vaccinated/infected individuals. We show that the breadth and potency of the antibody-mediated response is influenced by the number, the variant, and the nature (infection or vaccination) of exposures, and that individuals with mixed immunity acquired by vaccination and natural exposure exhibit the broadest and most potent responses. Our results suggest that the interplay between host immunity and SARS-CoV-2 evolution will shape the antigenicity and subsequent transmission dynamics of SARS-CoV-2, with important implications for future vaccine design.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willett, Professor Brian and Gunson, Dr Rory and Logan, Miss Nicola and Amat, Mr Julien and Bissett, Ms Laura and Hughes, Ms Ellen and Scott, Mr Sam and Thomson, Professor Emma and Viana, Dr Mafalda and Harvey, Dr William and Murcia, Professor Pablo and Orton, Dr Richard
Authors: Manali, M., Bissett, L. A., Amat, J. A.R., Logan, N., Scott, S., Hughes, E. C., Harvey, W. T., Orton, R., Thomson, E. C., Gunson, R. N., Viana, M., Willett, B., and Murcia, P. R.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Journal of Infectious Diseases
Publisher:Oxford University Press
ISSN:0022-1899
ISSN (Online):1537-6613
Published Online:03 August 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of Infectious Diseases 2022
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172630002Respiratory Infections: Epidemiology, evolution and ecology of respiratory viruses (Programme 1)Pablo MurciaMedical Research Council (MRC)MC_UU_12014/9III - Centre for Virus Research