Mechanisms shared between cancer, heart failure, and targeted anti-cancer therapies

de Wit, S., Glen, C., de Boer, R. A. and Lang, N. N. (2022) Mechanisms shared between cancer, heart failure, and targeted anti-cancer therapies. Cardiovascular Research, 118(8), pp. 3451-3466. (doi: 10.1093/cvr/cvac132) (PMID:36004495) (PMCID:PMC9897696)

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Heart failure (HF) and cancer are the leading causes of death worldwide and accumulating evidence demonstrates that HF and cancer affect one another in a bidirectional way. Patients with HF are at increased risk for developing cancer, and HF is associated with accelerated tumour growth. The presence of malignancy may induce systemic metabolic, inflammatory, and microbial alterations resulting in impaired cardiac function. In addition to pathophysiologic mechanisms that are shared between cancer and HF, overlaps also exist between pathways required for normal cardiac physiology and for tumour growth. Therefore, these overlaps may also explain the increased risk for cardiotoxicity and HF as a result of targeted anti-cancer therapies. This review provides an overview of mechanisms involved in the bidirectional connection between HF and cancer, specifically focusing upon current ‘hot-topics’ in these shared mechanisms. It subsequently describes targeted anti-cancer therapies with cardiotoxic potential as a result of overlap between their anti-cancer targets and pathways required for normal cardiac function.

Item Type:Articles
Additional Information:NNL is supported by a British Heart Foundation Centre of Research Excellence Grant (RE/18/6/34217). RAdB is supported by by the European Research Council (ERC CoG 818715); by the Netherlands Heart Foundation (grants 2017-21; 2017-11; 2018-30; 2020B005), by the leDucq Foundation (Cure-PLaN).
Glasgow Author(s) Enlighten ID:Lang, Professor Ninian and Glen, Dr Claire
Authors: de Wit, S., Glen, C., de Boer, R. A., and Lang, N. N.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Cardiovascular Research
Publisher:Oxford University Press
ISSN (Online):1755-3245
Published Online:25 August 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Cardiovascular Research 118(8): 3451-3466
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceColin BerryBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science