Manzano, J. S., Hou, W., Zalesskiy, S. S., Frei, P., Wang, H., Kitson, P. J. and Cronin, L. (2022) An autonomous portable platform for universal chemical synthesis. Nature Chemistry, 14(11), pp. 1311-1318. (doi: 10.1038/s41557-022-01016-w) (PMID:36202987)
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Abstract
Robotic systems for synthetic chemistry are becoming more common, but they are expensive, fixed to a narrow set of reactions, and must be used within a complex laboratory environment. A portable system that could synthesize known molecules anywhere, on demand, and in a fully automated way, could revolutionize access to important molecules. Here we present a portable suitcase-sized chemical synthesis platform containing all the modules required for synthesis and purification. The system uses a chemical programming language coupled to a digital reactor generator to produce reactors and executable protocols based on text-based literature syntheses. Simultaneously, the platform generates a reaction pressure fingerprint, used to monitor processes within the reactors and remotely perform a protocol quality control. We demonstrate the system by synthesizing five small organic molecules, four oligopeptides and four oligonucleotides, in good yields and purities, with a total of 24,936 base steps executed over 329 h of platform runtime.
Item Type: | Articles |
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Additional Information: | The authors gratefully acknowledge financial support from the EPSRC (grants nos. EP/L023652/1, EP/R020914/1, EP/S030603/1, EP/R01308X/1, EP/S017046/1 and EP/S019472/1), the ERC (project no. 670467 SMART-POM), the EC (project no. 766975 MADONNA) and DARPA (projects nos. W911NF-18-2-0036, W911NF-17-1-0316 and HR001119S0003). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Zalesskiy, Dr Sergey and Wang, Hsin and Hou, Dr Wenduan and Manzano, Dr Sebastian and Cronin, Professor Lee and Kitson, Dr Philip and Frei, Przemyslaw |
Authors: | Manzano, J. S., Hou, W., Zalesskiy, S. S., Frei, P., Wang, H., Kitson, P. J., and Cronin, L. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Nature Chemistry |
Publisher: | Nature Research |
ISSN: | 1755-4330 |
ISSN (Online): | 1755-4349 |
Published Online: | 06 October 2022 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Nature Chemistry 14(11): 1311-1318 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
Data DOI: | 10.5281/zenodo.5248762 |
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