First comprehensive analysis of Aedes aegypti bionomics during an arbovirus outbreak in west Africa: dengue in Ouagadougou, Burkina Faso, 2016-2017

Badolo, A. et al. (2022) First comprehensive analysis of Aedes aegypti bionomics during an arbovirus outbreak in west Africa: dengue in Ouagadougou, Burkina Faso, 2016-2017. PLoS Neglected Tropical Diseases, 16(7), e0010059. (doi: 10.1371/journal.pntd.0010059) (PMID:35793379) (PMCID:PMC9321428)

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Abstract

Background: Dengue’s emergence in West Africa was typified by the Burkina Faso outbreaks in 2016 and 2017, the nation’s largest to date. In both years, we undertook three-month surveys of Aedes populations in or near the capital city Ouagadougou, where the outbreaks were centered. Methodology: In 1200LG (urban), Tabtenga (peri-urban) and Goundry (rural) localities, we collected indoor and outdoor resting mosquito adults, characterized larval habitats and containers producing pupae and reared immature stages to adulthood in the laboratory for identification. All mosquito adults were identified morphologically. Host species (from which bloodmeals were taken) were identified by PCR. Generalized mixed models were used to investigate relationships between adult or larval densities and multiple explanatory variables. Results: From samples in 1,780 houses, adult Ae. aegypti were significantly more abundant in the two urban localities (Tabtenga and 1200 LG) in both years than in the rural site (Goundry), where Anopheles spp. were far more common. Results from adult collections indicated a highly exophilic and anthropophilic (>90% bloodmeals of human origin) vector population, but with a relatively high proportion of bloodfed females caught inside houses. Habitats producing most pupae were waste tires (37% of total pupae), animal troughs (44%) and large water barrels (30%). While Stegomyia indices were not reliable indicators of adult mosquito abundance, shared influences on adult and immature stage densities included rainfall and container water level, collection month and container type/purpose. Spatial analysis showed autocorrelation of densities, with a partial overlap in adult and immature stage hotspots. Conclusion: Results provide an evidence base for the selection of appropriate vector control methods to minimize the risk, frequency and magnitude of future outbreaks in Ouagadougou. An integrated strategy combining community-driven practices, waste disposal and insecticide-based interventions is proposed. The prospects for developing a regional approach to arbovirus control in West Africa or across Africa are discussed.

Item Type:Articles
Additional Information:The study was funded under a WHO/ TDR fellowship awarded to AB in collaboration with DW and PJM under the reference number WHO/TDR/ RCS-KM 2015 ID235974. PJM’s research on peri-domestic behavior of Aedes aegypti receives support from MRC-UK (MR/T001267/1). M.V. was funded by the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 852957).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Viana, Dr Mafalda
Creator Roles:
Viana, M.Formal analysis, Software, Validation, Visualization, Writing – review and editing
Authors: Badolo, A., Sombié, A., Yaméogo, F., Wangrawa, D. W., Sanon, A., Pignatelli, P. M., Sanon, A., Viana, M., Kanuka, H., Weetman, D., and McCall, P. J.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:PLoS Neglected Tropical Diseases
Publisher:Public Library of Science
ISSN:1935-2727
ISSN (Online):1935-2735
Published Online:06 July 2022
Copyright Holders:Copyright © 2022 Badolo et al.
First Published:First published in PLoS Neglected Tropical Diseases 16(7): e0010059
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
305702Towards malaria elimination: destabilizing shrinking mosquito populationsMafalda VianaEuropean Research Council (ERC)852957Institute of Biodiversity, Animal Health and Comparative Medicine