Protein biomarkers and cardiovascular outcomes in people with type 2 diabetes and acute coronary syndrome: the ELIXA biomarker study

Gerstein, H. C. et al. (2022) Protein biomarkers and cardiovascular outcomes in people with type 2 diabetes and acute coronary syndrome: the ELIXA biomarker study. Diabetes Care, 45(9), pp. 2152-2155. (doi: 10.2337/dc22-0453) (PMID:35817031)

Abstract

Objective: To use protein biomarkers to identify people with type 2 diabetes at high risk of cardiovascular outcomes and death. Research Design and Methods: Biobanked serum from 4,957 ELIXA (Evaluation of Lixisenatide in Acute Coronary Syndrome) trial participants was analyzed. Forward-selection Cox models identified independent protein risk factors for major adverse cardiovascular events (MACE) and death that were compared with a previously validated biomarker panel. Results: NT-proBNP and osteoprotegerin predicted both outcomes. In addition, trefoil factor 3 predicted MACE, and angiopoietin-2 predicted death (C = 0.70 and 0.79, respectively, compared with 0.63 and 0.66 for clinical variables alone). These proteins had all previously been identified and validated. Notably, C statistics for just NT-proBNP plus clinical risk factors were 0.69 and 0.78 for MACE and death, respectively. Conclusions: NT-proBNP and other proteins independently predict cardiovascular outcomes in people with type 2 diabetes following acute coronary syndrome. Adding other biomarkers only marginally increased NT-proBNP’s prognostic value.

• Item Type: Articles
• Additional Information: The ELIXA trial as well as the ELIXA biomarker substudy was funded by Sanofi. J.J.V.M. is supported by a British Heart Foundation Centre of Research Excellence Grant.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMurray, Professor John and Kober, Professor Lars
• Authors: Gerstein, H. C., Hess, S., Claggett, B., Dickstein, K., Kober, L., Maggioni, A. P., McMurray, J. J.V., Probstfield, J. L., Riddle, M. C., Tardif, J.-C., and Pfeffer, M. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Diabetes Care
• Publisher: American Diabetes Association
• ISSN: 0149-5992
• ISSN (Online): 1935-5548
• Published Online: 11 July 2022
• Copyright Holders: Copyright © 2022 by the American Diabetes Association
• First Published: First published in Diabetes Care 45(9):2152-2155
• Publisher Policy: Reproduced in accordance with the publisher copyright policy