Bovine papillomavirus infection in equine sarcoids and in bovine bladder cancers

Yuan, Z., Gallagher, A., Gault, E., Campo, S. and Nasir, L. (2007) Bovine papillomavirus infection in equine sarcoids and in bovine bladder cancers. Veterinary Journal, 174(3), pp. 599-604. (doi: 10.1016/j.tvjl.2006.10.012)

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Bovine papillomavirus (BPV) type 2 is involved in carcinogenesis of the urinary bladder in cattle, while BPV-1 is commonly associated with equine sarcoid tumours. In both cases the early viral proteins are expressed, but virion is not produced. Given the similarities in BPV biology between the tumours in cattle and horses, bovine bladder cancers and equine sarcoids were compared with respect to physical status, load of viral DNA and variability of the E5 open reading frame (ORF). Rolling circle amplification demonstrated that BPV-1 and BPV-2 genomes exist as double stranded, episomal, circular forms in the two tumours. Realtime quantitative PCR revealed that equine sarcoids contained higher viral DNA loads compared to bovine bladder cancers. The BPV-1 E5 ORF showed sequence variation but BPV-2 ORF did not. The presence of BPV-1 E5 variations or their absence in the BPV-2 E5 ORF does not appear to have an effect on viral DNA load in either tumour type.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Gault, Mrs Elizabeth and Campo, Professor Saveria and Nasir, Professor Lubna and Gallagher, Dr Alice and Yuan, Dr Zhengqiang
Authors: Yuan, Z., Gallagher, A., Gault, E., Campo, S., and Nasir, L.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Veterinary Journal
Publisher:Elsevier Ltd
ISSN (Online):1532-2971

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