Vaccine-induced time- and age-dependent mucosal immunity to gastrointestinal parasite infection

Liu, W., McNeilly, T. M., Mitchell, M., Burgess, S. T.G., Nisbet, A. J., Matthews, J. B. and Babayan, S. A. (2022) Vaccine-induced time- and age-dependent mucosal immunity to gastrointestinal parasite infection. npj Vaccines, 7, 78. (doi: 10.1038/s41541-022-00501-0) (PMID:35798788) (PMCID:PMC9262902)

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Abstract

Individuals vary broadly in their response to vaccination and subsequent challenge infection, with poor vaccine responders causing persistence of both infection and transmission in populations. Yet despite having substantial economic and societal impact, the immune mechanisms that underlie such variability, especially in infected tissues, remain poorly understood. Here, to characterise how antihelminthic immunity at the mucosal site of infection developed in vaccinated lambs, we inserted gastric cannulae into the abomasa of three-month- and six-month-old lambs and longitudinally analysed their local immune response during subsequent challenge infection. The vaccine induced broad changes in pre-challenge abomasal immune profiles and reduced parasite burden and egg output post-challenge, regardless of age. However, age affected how vaccinated lambs responded to infection across multiple immune pathways: adaptive immune pathways were typically age-dependent. Identification of age-dependent and age-independent protective immune pathways may help refine the formulation of vaccines, and indicate specificities of pathogen-specific immunity more generally.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Babayan, Dr Simon and Nisbet, Dr Alasdair and Mcneilly, Dr Tom
Authors: Liu, W., McNeilly, T. M., Mitchell, M., Burgess, S. T.G., Nisbet, A. J., Matthews, J. B., and Babayan, S. A.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:npj Vaccines
Publisher:Nature Research
ISSN:2059-0105
ISSN (Online):2059-0105
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in npj Vaccines 7: 78
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
171201Dissecting variation in host responsiveness to a recombinant vaccine designed to control teladorsagiosis in sheepSimon BabayanBiotechnology and Biological Sciences Research Council (BBSRC)BB/M012956/1Institute of Biodiversity, Animal Health and Comparative Medicine