Genetic diversity of Cryptosporidium hominis in a Bangladeshi community as revealed by whole-genome sequencing

Gilchrist, C. A. et al. (2018) Genetic diversity of Cryptosporidium hominis in a Bangladeshi community as revealed by whole-genome sequencing. Journal of Infectious Diseases, 218(2), pp. 259-264. (doi: 10.1093/infdis/jiy121) (PMID:29514308) (PMCID:PMC6009673)

Abstract

We studied the genetic diversity of Cryptosporidium hominis infections in slum-dwelling infants from Dhaka over a 2-year period. Cryptosporidium hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole-genome resequencing. Recombination in the parasite was evidenced by the decay of linkage disequilibrium in the genome over <300 bp. Regions of the genome with high levels of polymorphism were also identified. Yet to be determined is if genomic diversity is responsible in part for the high rate of reinfection, seasonality, and varied clinical presentations of cryptosporidiosis in this population.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cotton, Professor James
• Authors: Gilchrist, C. A., Cotton, J. A., Burkey, C., Arju, T., Gilmartin, A., Lin, Y., Ahmed, E., Steiner, K., Alam, M., Ahmed, S., Robinson, G., Zaman, S. U., Kabir, M., Sanders, M., Chalmers, R. M., Ahmed, T., Ma, J. Z., Haque, R., Faruque, A. S.G., Berriman, M., and Petri, W. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Journal of Infectious Diseases
• Publisher: Oxford University Press
• ISSN: 0022-1899
• ISSN (Online): 1537-6613
• Published Online: 05 March 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Journal of Infectious Diseases 218(2): 259-264
• Publisher Policy: Reproduced under a Creative Commons License