Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records

Thompson, E. J. et al. (2022) Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records. Nature Communications, 13, 3528. (doi: 10.1038/s41467-022-30836-0) (PMID:35764621) (PMCID:PMC9240035)

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The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.

Item Type:Articles
Additional Information:** From Springer Nature via Jisc Publications Router ** History: received 22-09-2021; accepted 19-05-2022; registration 23-05-2022; pub-electronic 28-06-2022; online 28-06-2022; collection 12-2022. ** Licence for this article: http://creativecommons.org/licenses/by/4.0/
Keywords:Article, /692/699/255/2514, /692/499, /692/308/174, /631/326/596/4130, article
Glasgow Author(s) Enlighten ID:Katikireddi, Professor Vittal and Green, Dr Michael and Niedzwiedz, Dr Claire
Authors: Thompson, E. J., Williams, D. M., Walker, A. J., Mitchell, R. E., Niedzwiedz, C. L., Yang, T. C., Huggins, C. F., Kwong, A. S. F., Silverwood, R. J., Di Gessa, G., Bowyer, R. C. E., Northstone, K., Hou, B., Green, M. J., Dodgeon, B., Doores, K. J., Duncan, E. L., Williams, F. M. K., Steptoe, A., Porteous, D. J., McEachan, R. R. C., Tomlinson, L., Goldacre, B., Patalay, P., Ploubidis, G. B., Katikireddi, S. V., Tilling, K., Rentsch, C. T., Timpson, N. J., Chaturvedi, N., and Steves, C. J.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
Journal Name:Nature Communications
Publisher:Nature Research
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Nature Communications 13: 3528
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172690Understanding the impacts of welfare policy on health: A novel data linkage studySrinivasa KatikireddiOffice of the Chief Scientific Adviser (CSO)SCAF/15/02SHW - Public Health
3048230021Inequalities in healthAlastair LeylandMedical Research Council (MRC)MC_UU_00022/2HW - MRC/CSO Social and Public Health Sciences Unit
3048230071Inequalities in healthAlastair LeylandOffice of the Chief Scientific Adviser (CSO)SPHSU17HW - MRC/CSO Social and Public Health Sciences Unit