Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers

Kemp, S. A. et al. (2022) Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers. Scientific Reports, 12, 10492. (doi: 10.1038/s41598-022-14411-7) (PMID:35729228) (PMCID:PMC9212198)

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Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-vaccinated patients and health care workers and have highlighted the benefits of high-grade respiratory protection for health care workers. However the extent to which vaccination is preventative of viral spread in health care settings is less well studied. Here, we analysed data from 118 vaccinated health care workers (HCW) across two hospitals in India, constructing two probable transmission networks involving six HCWs in Hospital A and eight HCWs in Hospital B from epidemiological and virus genome sequence data, using a suite of computational approaches. A maximum likelihood reconstruction of transmission involving known cases of infection suggests a high probability that doubly vaccinated HCWs transmitted SARS-CoV-2 between each other and highlights potential cases of virus transmission between individuals who had received two doses of vaccine. Our findings show firstly that vaccination may reduce rates of transmission, supporting the need for ongoing infection control measures even in highly vaccinated populations, and secondly we have described a novel approach to identifying transmissions that is scalable and rapid, without the need for an infection control infrastructure.

Item Type:Articles
Additional Information:R.K.G. is supported by a Wellcome Trust Senior Fellowship in Clinical Science (WT108082AIA). S.A.K. is supported by the Bill and Melinda Gates Foundation via PANGEA grant (OPP1175094). CJRI was supported by the Medical Research Council (MC_UU_12014).
Glasgow Author(s) Enlighten ID:Illingworth, Dr Chris
Authors: Kemp, S. A., Cheng, M. T. K., Hamilton, W. L., Kamelian, K., Chauhan, H., Dikid, T., Gogia, H., Lall, H., Ponnusamy, K., Verma, K., Dhar, M. S., Singh, M. K., Datta, M., Soni, N., Meena, N., Madan, P., Singh, P., Sharma, R., Sharma, R., Kabra, S., Kumar, S., Kumari, S., Sharma, U., Chaudhary, U., Sivasubbu, S., Scaria, V., Wattal, C., Oberoi, J. K., Raveendran, R., Datta, S., Das, S., Maitra, A., Chinnaswamy, S., Biswas, N. K., Parida, A., Raghav, S. K., Prasad, P., Sarin, A., Mayor, S., Ramakrishnan, U., Palakodeti, D., Seshasayee, A. S. N., Thangaraj, K., Bashyam, M. D., Dalal, A., Bhat, M., Shouche, Y., Pillai, A., Abraham, P., Potdar, V. A., Cherian, S. S., Desai, A. S., Pattabiraman, C., Manjunatha, M. V., Mani, R. S., Udupi, G. A., Nandicoori, V., Tallapaka, K. B., Sowpati, D. T., Singh, S., Rakshit, P., Agrawal, A., Illingworth, C. J.R., and Gupta, R. K.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Scientific Reports
Publisher:Nature Research
ISSN (Online):2045-2322
Copyright Holders:Copyright © The Author(s) 2022
First Published:First published in Scientific Reports 12: 10492
Publisher Policy:Reproduced under a Creative Commons Licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
315250MRC PE seed funding - John McLauchlanJohn McLauchlanMedical Research Council (MRC)MC_UU_12014III - Centre for Virus Research