TANDEM ZINC-FINGER/PLUS3 regulates phytochrome B abundance and signaling to fine-tune hypocotyl growth

Fang, W., Vellutini, E., Perrella, G. and Kaiserli, E. (2022) TANDEM ZINC-FINGER/PLUS3 regulates phytochrome B abundance and signaling to fine-tune hypocotyl growth. Plant Cell, 34(11), pp. 4213-4231. (doi: 10.1093/plcell/koac236) (PMID:35929801) (PMCID:PMC9614508)

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TANDEM ZINC-FINGER/PLUS3 (TZP) is a transcriptional regulator that acts at the crossroads of light and photoperiodic signaling. Here, we unveil a role for TZP in fine-tuning hypocotyl elongation under red light and long-day conditions. We provide genetic evidence for a synergistic action between TZP and PHOTOPERIODIC CONTROL OF HYPOCOTYL 1 (PCH1) in regulating the protein abundance of PHYTOCHROME INTERACTING FACTOR 4 (PIF4) and downstream gene expression in response to red light and long days (LDs). Furthermore, we show that TZP is a positive regulator of the red/far-red light receptor and thermosensor phytochrome B (phyB) by promoting phyB protein abundance, nuclear body formation, and signaling. Our data therefore assign a function to TZP in regulating two key red light signaling components, phyB and PIF4, but also uncover a new role for PCH1 in regulating hypocotyl elongation in LDs. Our findings provide a framework for the understanding of the mechanisms associated with the TZP signal integration network and their importance for optimizing plant growth and adaptation to a changing environment.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Fang, Weiwei and Perrella, Dr Giorgio and Kaiserli, Dr Eirini and Vellutini, Miss Elisa
Authors: Fang, W., Vellutini, E., Perrella, G., and Kaiserli, E.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Plant Cell
Publisher:Oxford University Press
ISSN (Online):1532-298X
Published Online:05 August 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Plant Cell 34(11): 4213-4231
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
171989Transcriptional regulation of plant growth in nuclear microdomainsEirini KaiserliBiotechnology and Biological Sciences Research Council (BBSRC)BB/M023079/1Institute of Molecular, Cell & Systems Biology