Walsh, D., Katris, N. J., Sheiner, L. and Botté, C. Y. (2022) Toxoplasma metabolic flexibility in different growth conditions. Trends in Parasitology, 38(9), pp. 775-790. (doi: 10.1016/j.pt.2022.06.001) (PMID:35718642)
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Abstract
Apicomplexan parasites have complex metabolic networks that coordinate acquisition of metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has a wide host range and may rely on the flexibility of this metabolic network. Currently, the literature categorizes genes as essential or dispensable according to their dispensability for parasite survival under nutrient-replete in vitro conditions. However, recent studies revealed correlations between medium composition and gene essentiality. Therefore, nutrient availability in the host environment likely determines the requirement of metabolic pathways, which may redefine priorities for drug target identification in a clinical setting. Here we review the recent work characterizing some of the major Toxoplasma metabolic pathways and their functional adaptation to host nutrient content.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work is supported by Agence Nationale de la Recherche, France (Project ApicoLipiAdapt ANR-21-CE44-0010 ), Finovi programs (Apicoplipid project) IDEX- Université Grenoble Alpes, Region Auvergne Rhone-Alpes (IRICE Grant, Project GEMELI), the Laboratoire d’Excellence ParaFrap, France (Grant number ANR-11-LABX-0024 ), The Fondation pour la Recherche Médicale (FRM EQU202103012700 ), CNRS LIA-IRP (project Apicolipid), CEFIPRA (project 6003-1 ) to C.Y.B.; and the MRC MR/S024573/1 grant and Wellcome Investigator Award 217173/Z/19/Z to L.S. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Walsh, Daniel and Sheiner, Professor Lilach |
| Authors: | Walsh, D., Katris, N. J., Sheiner, L., and Botté, C. Y. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Parasitology |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 1471-4922 |
| ISSN (Online): | 1471-5007 |
| Published Online: | 16 June 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Trends in Parasitology 38(9): 775-790 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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