Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386

McHugh, R. E., Munnoch, J. T., Roe, A. J. and Hoskisson, P. A. (2022) Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386. Access Microbiology, 4(5), 000358. (doi: 10.1099/acmi.0.000358) (PMID:36003359) (PMCID:PMC9394534)

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We report the genome sequence of Streptomyces goldiniensis ATCC 21386, a strain which produces the anti-bacterial and anti-virulence polyketide, aurodox. The genome of S. goldiniensis ATCC 21386 was sequenced using a multiplatform hybrid approach, revealing a linear genome of ~10 Mbp with a G+C content of 71%. The genome sequence revealed 36 putative biosynthetic gene clusters (BGCs), including a large region of 271 Kbp that was rich in biosynthetic capability. The genome sequence is deposited in DDBJ/EMBL/GenBank with the accession number PRJNA602141.

Item Type:Articles
Additional Information:We would like to thank the University of Strathclyde and University of Glasgow for jointly funding the PhD of REM. PAH would also like to acknowledge funding from BBSRC (BB/T001038/1 and BB/T004126/1) and the Royal Academy of Engineering Research Chair Scheme for long term personal research support (RCSRF2021\11\15). AJR and PAH would like to acknowledge funding from MRC (MR/V011499/1).
Keywords:General Materials Science
Glasgow Author(s) Enlighten ID:Roe, Professor Andrew and McHugh, Ms Rebecca
Authors: McHugh, R. E., Munnoch, J. T., Roe, A. J., and Hoskisson, P. A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Access Microbiology
Publisher:Microbiology Society
ISSN (Online):2516-8290
Published Online:30 May 2022
Copyright Holders:Copyright © The Author(s) 2022
First Published:First published in Access Microbiology 4(5): 000358
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
311034Aversion Therapy for Bacteria: Repurposing AurodoxAndrew RoeMedical Research Council (MRC)MR/V011499/1Chemistry