Recent insights into the effects of metabolism on breast cancer cell dormancy

Bartlome, S. and Berry, C. C. (2022) Recent insights into the effects of metabolism on breast cancer cell dormancy. British Journal of Cancer, 127(8), pp. 1385-1393. (doi: 10.1038/s41416-022-01869-5) (PMID:35715635) (PMCID:PMC9553927)

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Abstract

Breast cancer (BC) remains the most common cancer, as well as the leading cause of cancer mortality in women worldwide [1]. Approximately 30% of patients with early-stage BC experience metastasis or a recurrent form of the disease [2]. The phenomenon of BC dormancy, where metastasised cancer cells remain in a quiescent phase at their disseminated location and for unknown reasons can become actively proliferative again, further adds to BC’s clinical burden with treatment at this secondary stage typically proving futile. An emerging avenue of research focuses on the metabolic properties of dormant BC cells (BCCs) and potential metabolic changes causing BCCs to enter/exit their quiescent state. Here we explore several studies that have uncovered changes in carbon metabolism underlying a dormant state, with conflicting studies uncovering shifts towards both glycolysis and/or oxidative phosphorylation. This review highlights that the metabolic states/shifts of dormant BCCs seem to be dependent on different BC subtypes and receptor status; however, more work needs to be done to fully map these differences. Building on the research that this review outlines could provide new personalised therapeutic possibilities for BC patients.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Dr Catherine and Bartlome, Sara
Authors: Bartlome, S., and Berry, C. C.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:British Journal of Cancer
Publisher:Springer Nature
ISSN:0007-0920
ISSN (Online):1532-1827
Published Online:17 June 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in British Journal of Cancer 127(8): 1385-1393
Publisher Policy:Reproduced under a Creative Commons License

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